Center for Ecogenetics and Environmental Health

生态遗传学和环境健康中心

基本信息

批准号：
7651765
负责人：
David L Eaton
金额：
$ 15.6万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7651765
关键词：
ABCB1 gene ABCC1 gene ATP-Binding Cassette Transporters Adopted Adverse effects Affect Anesthetics Apoptosis Aromatic Amines Aromatic Hydrocarbons Benign Biochemical Bioinformatics Biological Biometry CYP2C9 gene CYP2D6 gene CYP3A5 gene Cancerous Carcinogens Cardiovascular system Carrier Proteins Cell Death Chemicals Chronic Code Communities Community Health Education Community Outreach Complex Core Facility Cyclosporine Cyclosporins Cytochrome P450 Cytology Cytometry DNA Data Development Dietary Component Diffusion Drug Metabolic Detoxication Ductal Epithelium Education and Outreach Environment Environmental Exposure Environmental Health Enzymes Epithelial Cells Epoxide hydrolase Equilibrium Etiology Event Excretory function Exposure to Faculty Failure Fingerprint Flow Cytometry Fluorescence Fostering Funding Gastrointestinal tract structure Gene Expression Genes Genetic Genetic Determinism Genetic Predisposition to Disease Genetic Screening Genetic Transformation Glutathione S-Transferase Hepatic Hepatotoxicity Human Individual Individual Differences Inflammatory Response Injury Interdisciplinary Study Intestines Investigation Kidney Kidney Diseases Lead Learning Liver Maintenance Malignant neoplasm of pancreas Mammals Membrane Mercury Messenger RNA Metabolic Metabolic Biotransformation Metabolism Methodology Methods Modeling Modification Molecular Mutation Mycotoxins Nitrosamines Nucleoside Transporter Organ Outcome P-Glycoprotein P-Glycoproteins Pancreas Parathion Parents Pathway interactions Pattern Pharmaceutical Preparations Pilot Projects Play Population Predisposition Process Proteins Proteome Proteomics Pump Purpose Recording of previous events Research Research Infrastructure Research Personnel Research Project Grants Risk Risk Factors Role Series Services Signal Transduction Source Substrate Specificity System Tacrolimus Techniques Teratogens Therapeutic Tissues Toxic Environmental Substances Toxic effect Toxicant exposure Toxicology Toxin Transgenic Animals Translating Tubular formation Universities Variant Wood material Work Xenobiotics acetaminophen cysteine assay development austin base cancer risk carcinogenesis cell injury direct application disorder risk ethical legal social implication extracellular flavin-containing monooxygenase functional genomics gastrointestinal gene environment interaction innovation kidney cell kidney epithelial cell macromolecule neurotoxic neurotoxicology programs reproductive respiratory response toxicant trait trimethylamine uptake

项目摘要

The theme of this Center is "Biochemical and Molecular Mechanisms Underlying Human Variability in Response to Environmental Exposures". The interactions between genetics and environment are complex, and defy explanation through traditional disciplinary pathways of investigation. The purpose of this NIEHS Center is to provide an administrative infrastructure and technical support to foster the multidisciplinary collaborations necessary to extend basic mechanistic studies on environmental health problems to direct application in human populations. This center consists of 6 research cores: 1) Gastrointestinal & Renal Toxicology, 2) Carcinogenesis, 3) Reproductive and Developmental Toxicology, 4) Neurotoxicology, 5) Cardiovascular Respiratory Toxicology, 6) Bioinformatics & Biostatistical Methodologies. Each of these Cores consists of 7 - 10 senior investigators and 2 - 5 associate investigators representing several different Departments and programs throughout the University. The funded research of these core faculty is enhanced by 5 Facility cores which provide Center investigators access to: 1) Functional Genomics, 2) Functional Proteomics, 3) Analytical Cytology, techniques such as flow cytometry and fluorescence activated quantitative cytometry, 4) Transgenic Animal Services, support for development and maintenance of transgenic animals of value in toxicological research, and 5) Bioinformatics & Biostatistics, provides guidance for research statistical data. The Pilot Projects supports 5 exploratory research projects into innovative new ideas related to the theme of the Center for one year. A Community Outreach and Education Core provides a mechanism to disseminate important research findings of Center investigators to the general community, as well as a coordinating function to extend and enhance existing community education programs to include more emphasis on issues related to environmental health sciences. The Ethical, Legal & Social Issues (ELSI) Core provides the researchers with the latest information dealing with these issues.

该中心的主题是“人类变异性的生化和分子机制对环境暴露的反应”。遗传学与环境之间的相互作用很复杂，并通过传统的纪律调查途径违反解释。这个niehs的目的中心将提供管理基础架构和技术支持，以促进多学科扩展有关环境健康问题的基本机械研究所需的协作以指导在人口中的应用。该中心由6个研究核心组成：1）胃肠道和肾脏毒理学，2）癌变，3）生殖和发育毒理学，4）神经毒理学，5）心血管呼吸毒理学，6）生物信息学和生物统计学方法。每个核心由7-10名高级调查员和2-5名代表几个不同的副研究人员组成整个大学的部门和计划。这些核心教师的资助研究是通过5个设施核心增强，可为中心研究人员访问：1）功能基因组学，2）功能蛋白质组学，3）分析细胞学，流式细胞仪和荧光等技术激活定量细胞仪，4）转基因动物服务，支持开发和维护有价值的转基因动物在毒理学研究中，5）生物信息学和生物统计学提供研究统计数据指南。飞行员项目支持5个探索性研究项目创新的新想法与中心的主题一年有关。社区宣传和教育核心提供了一种将中心研究人员的重要研究结果传播到的机制一般社区以及协调功能，以扩展和增强现有社区教育计划更多地重视与环境健康科学有关的问题。道德，合法＆社会问题（ELSI）核心为研究人员提供了有关这些问题的最新信息。