Integrative Health Sciences

综合健康科学

• 批准号: 7434839
• 负责人: Seamus Thompson
• 金额: $ 46.23万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7434839
• 关键词: Address; Biological; Biological Assay; Biological Markers; Biometry; Collaborations; Communities; Community Outreach; Core Facility; DNA; DNA Adducts; Database Management Systems; Detection; Development; Education and Outreach; Environmental Exposure; Environmental Health; Epidemiology; Equipment; Equipment and supply inventories; Fostering; Functional disorder; Genome; Genotype; Goals; Health Sciences; Immunoassay; Laboratories; Measurement; Measures; Methodology; Methods; Modeling; Newsletter; Online Systems; Outcome; Oxidative Stress; Pilot Projects; Population; Postdoctoral Fellow; Process; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Sampling; Services; Shipping; Ships; Students; System; Techniques; Testing; Training; Training and Education; Upper arm; Work; base; cost; data management; human disease; human study; interest; member; patient oriented

A. Objectives/Specific Aims In the previous application, separate facility cores handled support for human studies by Center for Environmental Health in Northern Manhattan (CEHNM) members. Biospecimen processing and analysis was provided by the Biomarkers Facility Core, and support for study design, data management and statistical analysis by the Biostatistics Epidemiology and Data Management (BEDM) Facility Core. With the requirement by NIEHS for an Integrative Health Sciences Facility (IHS) Core, these two cores were combined in January of 2006. The overall goal of the IHS Facility Core is to facilitate both patient-oriented and population-based research within the CEHNM. It promotes the strategic goals of the CEHNM by supporting existing research projects and fostering new interdisciplinary activities focusing on environmental health problems. The Core provides the infrastructure to carry out these studies and has several components, including biospecimen processing, DNA extraction, genotyping and laboratory assays. Epidemiologic and biostatistical capabilities include collaboration on study design, power calculations, measurement of exposure, covariates, confounders and outcomes and data management and analysis. The biorepository arm of the IHS Core provides a centralized, efficient and cost-effective resource for collecting or receiving, processing, storing, distributing and analyzing biological samples. The Core also seeks to address the needs of CEHNM investigators as their research focus changes. The addition of high throughput genotyping methods was the result of member requests, as was the development of oxidative stress assays and enhancement of data management capabilities. It also develops and validates new assays to meet the changing needs of CEHNM investigators. In addition, the Core offers pro-bono or low-cost services to new CEHNM pilot projects. Training of students and postdoctoral fellows is an important component of Core activities, allowing methodologies to be exported to other laboratories, providing access to equipment and the expertise necessary to conduct studies requiring DNA adduct detection, measurement of oxidative stress markers, genotyping and other immunoassays of interest. The Core also provides extremely efficient, cost-effective cutting-edge web-based and other database management systems, which are expanding to include a major formal educational component. Finally, the IHS Facility Core works with the Community Outreach and Education Core (COEC) to disseminate research results to the surrounding community; its activities were highlighted in the most recent CEHNM newsletter.

A. 目标/具体目标 在之前的应用中，单独的设施核心处理了人类研究中心对人类研究的支持。 曼哈顿北部环境健康 (CEHNM) 成员。生物样本处理和分析是 由生物标记设施核心提供，并支持研究设计、数据管理和统计 由生物统计学流行病学和数据管理 (BEDM) 设施核心进行分析。随着要求 由 NIEHS 提出的综合健康科学设施 (IHS) 核心，这两个核心于一月份合并 2006 年。 IHS 设施核心的总体目标是促进以患者为中心和以人群为基础的研究 CEHNM 内。它通过支持现有的研究项目来促进 CEHNM 的战略目标 促进以环境健康问题为重点的新的跨学科活动。核心提供 进行这些研究的基础设施有几个组成部分，包括生物样本处理， DNA 提取、基因分型和实验室测定。流行病学和生物统计能力包括 在研究设计、功效计算、暴露测量、协变量、混杂因素和 结果以及数据管理和分析。 IHS Core 的生物样本库臂提供集中式、 用于收集或接收、处理、存储、分发和分析的高效且具有成本效益的资源 生物样本。该核心还致力于满足 CEHNM 研究人员的研究需求 焦点发生变化。增加高通量基因分型方法是会员请求的结果，如下： 是氧化应激测定的发展和数据管理能力的增强。它还 开发并验证新的检测方法，以满足 CEHNM 研究人员不断变化的需求。 此外，核心还为新的 CEHNM 试点项目提供无偿或低成本服务。学生培训 博士后研究员是核心活动的重要组成部分，允许输出方法 向其他实验室提供进行需要的研究所需的设备和专业知识 DNA加合物检测、氧化应激标记物测量、基因分型和其他免疫分析 兴趣。该核心还提供极其高效、具有成本效益的尖端基于网络和其他 数据库管理系统正在扩展到包括主要的正规教育组成部分。 最后，IHS 设施核心与社区外展和教育核心 (COEC) 合作， 向周围社区传播研究成果；最近的报告强调了其活动 CEHNM 通讯。