Synthetic Hemostats for Trauma Treatment
用于创伤治疗的合成止血剂
基本信息
- 批准号:9982122
- 负责人:
- 金额:$ 59.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:AbdomenAccident and Emergency departmentAffectAmbulancesAnimal ModelAnimalsAntifibrinolytic AgentsAortic InjuryBindingBiomedical EngineeringBiopolymersBlood Coagulation DisordersBlood Coagulation FactorBlood VesselsBlood coagulationCaringCause of DeathCessation of lifeChemical EngineeringChestClinicalCoagulation ProcessComb animal structureDoseDrug KineticsEarly-life traumaEmergency MedicineEngineeringEvaluationFamily suidaeFiberFibrinFibrinolysisFormulationGenerationsGoalsGuidelinesHeart DiseasesHemorrhageHemostatic AgentsHemostatic functionHistologicHospitalsHourImpairmentInjectableInjuryIntravenousLeadLifeLiquid substanceMalignant NeoplasmsMeasuresMechanicsMedicalMedicineMethodsModelingOperative Surgical ProceduresOrganOryctolagus cuniculusPathologyPathway interactionsPeptidesPharmaceutical PreparationsPharmacodynamicsPhasePolymersPre-Clinical ModelProcessProductionProteinsRattusRegimenResearch PersonnelResistanceResuscitationRodentRouteSafetySiteSolubilityStructureSurgeonTestingThrombinThrombosisTimeToxic effectTraffic accidentsTranexamic AcidTraumaTrauma patientTraumatic injuryUnited StatesUnited States Food and Drug AdministrationUniversitiesVertebral columnViolenceWashingtonWorkblood productclinical translationclinically relevantcostcrosslinkdesignfemoral arteryfirst responderhydrophilicityimmunogenicityimprovedinnovationintravenous injectionliver injurymeetingsmonomernew technologypolymerizationportabilitypre-clinicalpreventsafety testingside effectthrombogenesistrauma careviscoelasticitywound
项目摘要
PROJECT SUMMARY
Traumatic injuries, such as from road traffic accidents or intentional acts of violence, preferentially affects the
young, claims approximately 5 million lives annually, and accounts for more years of potential life lost in the
United States than cancer or heart disease. Hemorrhage is responsible for 30-40% of trauma-associated
deaths and is the leading cause of the death in the initial 6 hours after injury. Thus, there is a significant need
and potential clinical impact for new technologies that can be used by first responders to manage hemorrhage
in the initial time frame after trauma. This proposal seeks to develop an intravenous synthetic hemostat for
clinical translation for trauma care. The project team includes experts in trauma medicine, bioengineered
materials, structural analysis of soft materials, and animal pathology. We hypothesize that a synthetic
biopolymer that specifically recognizes and crosslinks fibrin, a protein component of clots, will stop bleeding at
wound sites after intravenous injection. In our preliminary work, we have designed an injectable, bioengineered
polymer and demonstrated its ability to integrate in forming clots and significantly improve survival in an animal
model of trauma when injected intravenously after injury. With the ultimate goal of clinical translation for this
material, this project proposes three aims: (i) define the optimal polymer structure and synthesis route, (ii)
evaluate the pharmacokinetics, safety profile and storage stability of the material, and (iii) establish efficacy in
multiple preclinical animal traumatic bleeding models. Upon completion of these aims, the team will be ready
for a pre-IND meeting with the FDA and be within a few years of an IND submission to the Food and Drug
Administration (FDA).
项目概要
外伤,例如道路交通事故或故意暴力行为,优先影响
每年约有 500 万人丧生,并导致更多年的潜在生命损失
美国比癌症或心脏病更重要。 30-40% 的创伤相关性出血是由出血造成的
死亡,并且是受伤后最初 6 小时内死亡的主要原因。因此,非常需要
以及急救人员可以用来控制出血的新技术的潜在临床影响
在创伤后的最初时间范围内。该提案旨在开发一种静脉内合成止血剂
创伤护理的临床翻译。项目团队包括创伤医学、生物工程专家
材料、软材料结构分析和动物病理学。我们假设合成
特异性识别并交联纤维蛋白(血凝块的蛋白质成分)的生物聚合物将在以下时间止血
静脉注射后的伤口部位。在我们的前期工作中,我们设计了一种可注射的生物工程
聚合物并展示了其整合形成凝块并显着提高动物存活率的能力
受伤后静脉注射的创伤模型。临床转化的最终目标是
材料,该项目提出了三个目标:(i)确定最佳聚合物结构和合成路线,(ii)
评估材料的药代动力学、安全性和储存稳定性,以及 (iii) 确定其功效
多个临床前动物创伤出血模型。完成这些目标后,团队将做好准备
与 FDA 举行 IND 前会议,并在向食品和药物管理局提交 IND 后的几年内
管理(FDA)。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
ENGINEERED INTRAVENOUS THERAPIES FOR TRAUMA.
专为创伤设计的静脉疗法。
- DOI:
- 发表时间:2023-09
- 期刊:
- 影响因子:0
- 作者:Pichon, Trey J;White, Nathan J;Pun, Suzie H
- 通讯作者:Pun, Suzie H
Optimizing the Polymer Chemistry and Synthesis Method of PolySTAT, an Injectable Hemostat.
优化注射止血剂 PolySTAT 的聚合物化学和合成方法。
- DOI:
- 发表时间:2020
- 期刊:
- 影响因子:5.8
- 作者:Lamm, Robert J;Pichon, Trey J;Huyan, Frederick;Wang, Xu;Prossnitz, Alexander N;Manner, Karl T;White, Nathan J;Pun, Suzie H
- 通讯作者:Pun, Suzie H
Leukocyte activation primes fibrinogen for proteolysis by mitochondrial oxidative stress.
白细胞活化促使纤维蛋白原通过线粒体氧化应激进行蛋白水解。
- DOI:
- 发表时间:2022-05
- 期刊:
- 影响因子:11.4
- 作者:Han, Chang Yeop;Pichon, Trey J;Wang, Xu;Ringgold, Kristyn M;St John, Alexander E;Stern, Susan A;White, Nathan J
- 通讯作者:White, Nathan J
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Suzie H. Pun其他文献
Reducible, dibromomaleimide-linked polymers for gene delivery
- DOI:
10.1039/c4bm00240g - 发表时间:
2014-08 - 期刊:
- 影响因子:6.6
- 作者:
James-Kevin Y. Tan;Jennifer L. Choi;Hua Wei;Joan G. Schellinger;Suzie H. Pun - 通讯作者:
Suzie H. Pun
Aptamers 101: aptamer discovery andin vitroapplications in biosensors and separations
- DOI:
10.1039/d3sc00439b - 发表时间:
2023-05 - 期刊:
- 影响因子:8.4
- 作者:
Lucy F. Yang;Melissa Ling;Nataly Kacherovsky;Suzie H. Pun - 通讯作者:
Suzie H. Pun
Polymeric biomaterials for cancer nanotechnology
- DOI:
10.1039/c5bm90025e - 发表时间:
2015-06 - 期刊:
- 影响因子:6.6
- 作者:
Jianjun Cheng;Suzie H. Pun - 通讯作者:
Suzie H. Pun
Identifying key barriers in cationic polymer gene delivery to human T cells
- DOI:
10.1039/c8bm01262h - 发表时间:
2018-12 - 期刊:
- 影响因子:6.6
- 作者:
Brynn R. Olden;Emmeline Cheng;Yilong Cheng;Suzie H. Pun - 通讯作者:
Suzie H. Pun
Formulation of thrombin-inhibiting hydrogelsviaself-assembly of ionic peptides with peptide-modified polymers
- DOI:
10.1039/d0sm00209g - 发表时间:
2020-04 - 期刊:
- 影响因子:3.4
- 作者:
Jason Lee;Tianyu Zhao;David J. Peeler;Daniel C. Lee;Trey J. Pichon;David Li;Kathleen M. Weigandt;Philip J. Horner;Lilo D. Pozzo;Drew L. Sellers;Suzie H. Pun - 通讯作者:
Suzie H. Pun
Suzie H. Pun的其他文献
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{{ truncateString('Suzie H. Pun', 18)}}的其他基金
Traceless, aptamer-based cell isolation for cell therapy applications
用于细胞治疗应用的无痕、基于适体的细胞分离
- 批准号:
10633756 - 财政年份:2023
- 资助金额:
$ 59.48万 - 项目类别:
An integrated polymeric carrier for subunit cancer vaccines
用于亚单位癌症疫苗的集成聚合物载体
- 批准号:
10576958 - 财政年份:2021
- 资助金额:
$ 59.48万 - 项目类别:
An integrated polymeric carrier for subunit cancer vaccines
用于亚单位癌症疫苗的集成聚合物载体
- 批准号:
10366085 - 财政年份:2021
- 资助金额:
$ 59.48万 - 项目类别:
An integrated polymeric carrier for subunit cancer vaccines
用于亚单位癌症疫苗的集成聚合物载体
- 批准号:
10229292 - 财政年份:2021
- 资助金额:
$ 59.48万 - 项目类别:
2022 Drug Carriers in Medicine and Biology GRC/GRS
2022年医学和生物学药物载体GRC/GRS
- 批准号:
10378904 - 财政年份:2021
- 资助金额:
$ 59.48万 - 项目类别:
Touchscreen-compatible, real-time electrochemical sensing of SARS-CoV-2
触摸屏兼容的 SARS-CoV-2 实时电化学传感
- 批准号:
10260946 - 财政年份:2020
- 资助金额:
$ 59.48万 - 项目类别:
Touchscreen-compatible, real-time electrochemical sensing of SARS-CoV-2
触摸屏兼容的 SARS-CoV-2 实时电化学传感
- 批准号:
10320986 - 财政年份:2020
- 资助金额:
$ 59.48万 - 项目类别:
POTENTIATING BREAST CANCER THERAPIES BY TARGETING TUMOR-ASSOCIATED MACROPHAGE
通过靶向肿瘤相关巨噬细胞来增强乳腺癌治疗
- 批准号:
8990828 - 财政年份:2014
- 资助金额:
$ 59.48万 - 项目类别:
POTENTIATING BREAST CANCER THERAPIES BY TARGETING TUMOR-ASSOCIATED MACROPHAGE
通过靶向肿瘤相关巨噬细胞来增强乳腺癌治疗
- 批准号:
8644613 - 财政年份:2014
- 资助金额:
$ 59.48万 - 项目类别:
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