STRUCTURAL AND FUNCTIONAL STUDIES OF EUKARYOTIC PHOSPHOFRUCTOKINASE

真核磷酸果糖激酶的结构和功能研究

• 批准号: 7602769
• 负责人: TERESA RUIZ
• 金额: $ 1.79万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-13 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602769
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Energy-Generating Resources; Enzymes; Fructose; Funding; Glycolysis; Grant; Institution; Lead; Phosphorylation; Play; Regulation; Research; Research Personnel; Resources; Role; Source; Structure-Activity Relationship; United States National Institutes of Health; cancer cell; cancer type; fructose-6-phosphate; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Phosphofructokinase (Pfk1) catalyzes a crucial regulatory step of glycolysis, the phosphorylation of fructose 6-phosphate (F6P) to fructose 1,6-biphosphate in the presence of ATP. The enzymatic activity of Pfk1 is controlled by many allosteric effectors, evidencing the key role that the enzyme plays in the regulation of the glycolytic flux. Glycolysis is the main energy source of cancer cells. Thus, a thorough understanding of the structure/function relationship in Pfk1 may lead to novel and more effective treatments for certain types of cancer.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 磷酸果糖激酶（PFK1）催化糖酵解的关键调节步骤，在ATP存在下，果糖6-磷酸（F6P）的磷酸化6-磷酸（F6P）的磷酸化为1,6-磷酸盐。 PFK1的酶促活性受许多变构效应子的控制，证明了酶在调节糖酵解通量中所起的关键作用。糖酵解是癌细胞的主要能源。因此，对PFK1中的结构/功能关系的透彻理解可能会导致针对某些类型的癌症的新颖和更有效的治疗方法。