THE STRUCTURE AND FUNCTION OF HUMAN PHAGOCYTE FLAVOCYTOCHROME B

人吞噬细胞黄细胞色素B的结构和功能

• 批准号: 7602740
• 负责人: ALGIRDAS JOSEPH JESAITIS
• 金额: $ 1.79万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-13 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602740
• 关键词: Animals; Cell membrane; Chronic Granulomatous Disease; Computer Retrieval of Information on Scientific Projects Database; Disease; Electrons; Enzymes; Funding; Glycoproteins; Grant; Host Defense; Human; Individual; Infection; Inflammatory; Institution; Life; Membrane; Multienzyme Complexes; NADPH Oxidase; Phagocytes; Plants; Production; Research; Research Personnel; Resources; Signal Transduction; Source; Structure; Superoxides; System; Transferase; United States National Institutes of Health; cytochrome b558; eosinophil; macrophage; monocyte; neutrophil; prototype; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Flavocytochrome b is the central electron transferase of the NADPH oxidase of neutrophils, eosinophils, and monocytes/macrophages. This phagosomal and plasma membrane enzyme system is responsible for generating superoxide for host defense. Individuals deficient in this enzyme complex suffer severe life threatening infections with a disease called chronic granulomatous disease. Unregulated superoxide production is also pathogenic in a wide variety of inflammatory diseases. The flavocytochrome has also now been recognized to a prototype for NADPH oxidases widely expressed in plants and animals serving in oxidative signaling and organismic defense. The 3D structure of flavocytochrome b, an integral membrane heterodimeric glycoprotein, remains unknown.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 黄细胞色素 b 是中性粒细胞、嗜酸性粒细胞和单核细胞/巨噬细胞的 NADPH 氧化酶的中心电子转移酶。这种吞噬体和质膜酶系统负责产生用于宿主防御的超氧化物。 缺乏这种酶复合物的个体会遭受严重危及生命的感染，患有一种称为慢性肉芽肿病的疾病。不受控制的超氧化物产生也是多种炎症性疾病的致病因素。黄细胞色素现已被认为是广泛表达于植物和动物中的 NADPH 氧化酶的原型，用于氧化信号传导和生物防御。黄细胞色素 b（一种完整膜异二聚体糖蛋白）的 3D 结构仍然未知。