CYCLIN C-ASSOCIATED PROTEINS

细胞周期蛋白 C 相关蛋白

• 批准号: 7602117
• 负责人: RANDY S STRICH
• 金额: $ 0.62万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602117
• 关键词: 26S proteasome; Binding; Computer Retrieval of Information on Scientific Projects Database; Cyclin-Dependent Kinases; Cyclins; Funding; Genes; Grant; Holoenzymes; Institution; Meiosis; Oxidative Stress; Proteins; RNA Polymerase II; Repression; Research; Research Personnel; Resources; Signal Transduction; Source; Ubiquitin; United States National Institutes of Health; Yeasts; biological adaptation to stress; cyclin C

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal focuses on the yeast C-type cyclin and the cyclin dependent kinase Cdk8. Cyclin C-Cdk8p binds the RNA polymerase II holoenzyme and represses both meiotic and stress response genes. To relieve this repression, cyclin C is destroyed thus uncovering a unique set of regulatory signals controlling cyclin turnover. We have found that the oxidative-stress induced destruction of cyclin C requires ubiquitin and the 26S proteasome. The focus of this study is to identify proteins that associate with cyclin C.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该提案着重于酵母C型细胞周期蛋白和细胞周期蛋白依赖性激酶CDK8。 Cyclin C-CDK8P结合RNA聚合酶II全酶，并抑制减数分裂和应激反应基因。 为了缓解这种抑制，细胞周期蛋白C被破坏，从而发现了一组独特的调节信号，以控制细胞周期蛋白更新。我们发现，氧化压力诱导的细胞周期蛋白C需要泛素和26S蛋白酶体。 这项研究的重点是鉴定与细胞周期蛋白相关的蛋白质。