CURCUMIN BINDING MODES IN HIV PROTEASE AND INTEGRASE ACTIVE SITES

HIV 蛋白酶和整合酶活性位点中的姜黄素结合模式

• 批准号: 7601705
• 负责人: OPA VAJRAGUPTA
• 金额: $ 0.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601705
• 关键词: Acquired Immunodeficiency Syndrome; Active Sites; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Asia; Binding; Biological; Computer Retrieval of Information on Scientific Projects Database; Curcuma longa; Curcumin; Endopeptidases; Exhibits; Funding; Grant; Growth; HIV; HIV-1; Institution; Integrase; Intervention; Malignant Neoplasms; Medicinal Plants; Nature; Peptide Hydrolases; Phosphotransferases; Protein Kinase; Protein Kinase C; Reporting; Research; Research Personnel; Resources; Rhizome; Source; System; Tumeric; Turmeric extract; United States National Institutes of Health; Zingiberaceae; bis(4-hydroxycinnamoyl)methane; carcinogenesis; demethoxycurcumin; gastrointestinal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS). The unique nature of the replication cycle of HIV-1 provides many potential targets for chemotherapeutic intervention. Curcuma longa Linn. or turmeric (Zingiberaceae) is a medicinal plant widely cultivated in tropical regions of Asia. Turmeric extract from the rhizomes commonly called curcumin is mainly composed of curcumin, about 75-95% and a small amount of demethoxy curcumin and bisdemethoxycurcumin. In addition to its potent antioxidant activity, various related activities in biological systems have been extensively investigated. Curcumin has been shown to exhibit anti-inflammatory, gastrointestinal activity, and inhibitory activity against a variety of protein kinases including protein kinase C and phosphoryl kinase. Curcumin is also reported to inhibit carcinogenesis and cancer growth. More recently, curcumin has been reported to inhibit HIV replication.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 1 型人类免疫缺陷病毒 (HIV-1) 是获得性免疫缺陷综合征 (AIDS) 的病原体。 HIV-1 复制周期的独特性质为化疗干预提供了许多潜在的靶标。姜黄。或姜黄（姜科）是一种在亚洲热带地区广泛种植的药用植物。姜黄根茎提取物俗称姜黄素，主要成分为姜黄素，约占75-95%，还有少量去甲氧基姜黄素和双去甲氧基姜黄素。除了其有效的抗氧化活性外，生物系统中的各种相关活性也已得到广泛研究。姜黄素已被证明具有抗炎、胃肠道活性以及对多种蛋白激酶（包括蛋白激酶 C 和磷酸激酶）的抑制活性。据报道，姜黄素还可以抑制致癌作用和癌症生长。最近，据报道姜黄素可以抑制艾滋病毒复制。