IN-VITRO AND IN-VIVO ULTRASTRUCTURAL STUDIES OF NEURONAL INFLAMMATION

神经炎症的体外和体内超微结构研究

• 批准号: 7598373
• 负责人: ALBERT S LOSSINSKY
• 金额: $ 0.11万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598373
• 关键词: Blood - brain barrier anatomy; Brain; Candida albicans; Computer Retrieval of Information on Scientific Projects Database; District of Columbia; Endothelial Cells; Filler; Funding; Grant; Human; In Vitro; Inflammation; Institution; Meningitis; Neonatal; Neuraxis; Neurons; Neurosciences; Paper; Pathology; Rattus; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Societies; Source; Specimen; United States National Institutes of Health; Visit; Yeasts; abstracting; high voltage electron microscopy; in vivo; interest

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ABSTRACT Dr. Lossinsky has been a user of the RVBC HVEM facility for many years. He has undertaken a variety studies related to pathology of the central nervous system. In this reporting period, he was interested in invasion of brain endothelial cells by Candida albicans yeast, and inflammation in neonatal rat meningitis. In the previous reporting period, Dr. Lossinsky visited the RVBC to use the HVEM for recording stereo pairs of his specimens, and the following paper was presented: " Lossinsky, A.S., Fiala, M., Mukhtar, M., Filler, S.G. Ultrastructural studies on blocking Candida albicans invasion into the human blood-brain barrier in culture by remodeling the endothelial cytoskeletal infrastructure. Abstract to be presented at the Society for Neuroscience Convention, Washington, DC, November 15, 2005.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 抽象的 Lossinsky 博士多年来一直是 RVBC HVEM 设施的用户。 他进行了与中枢神经系统病理学相关的各种研究。 在本报告期内，他对白色念珠菌对脑内皮细胞的侵袭以及新生大鼠脑膜炎的炎症感兴趣。 在上一个报告期，Lossinsky博士访问了RVBC，使用HVEM记录他的标本的立体声对，并提出了以下论文： “Lossinsky, A.S.、Fiala, M.、Mukhtar, M.、Filler, S.G. 通过重塑内皮细胞骨架基础设施来阻止白色念珠菌侵入培养物中的人血脑屏障的超微结构研究。摘要将在神经科学学会上发表大会，华盛顿特区，2005 年 11 月 15 日。