MITOCHONDRIAL SWIRLS

线粒体漩涡

• 批准号: 7598379
• 负责人: SEYMOUR BENZER
• 金额: $ 1.72万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598379
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Crista ampullaris; Drosophila genus; Funding; Grant; Institution; Membrane; Mitochondria; Muscle Mitochondria; Oxidative Stress; Peripheral; Research; Research Personnel; Resources; Shapes; Source; Structure; United States National Institutes of Health; abstracting; response; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ABSTRACT We see swirls in Drosophila flight muscle mitochondria in response to oxidative stress. 3D tomography is needed to see their detailed structure. Specifically, we want to know whether there are single or multiple cristae involved in swirl formation, how the swirl shape relates to the shape of normal cristae in these mitochondria, and whether the swirl cristae are attached to the peripheral region of the inner membrane (i.e. whether there are crista junctions).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 抽象的 我们看到果蝇飞行肌肉线粒体响应氧化应激而出现漩涡。需要 3D 断层扫描才能看到其详细结构。 具体来说，我们想知道是否有单个或多个嵴参与漩涡形成，漩涡形状与这些线粒体中正常嵴的形状如何相关，以及漩涡嵴是否附着在内膜的外围区域（即，线粒体）。是否有嵴交界处）。