STRUCTURE OF AMORPHOUS METAL-HALOGEN BIOMATERIALS IN ARTHROPED TOOLS

关节工具中非晶金属卤生物材料的结构

• 批准号: 7598039
• 负责人: ROBERT A SCOTT
• 金额: $ 1.29万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598039
• 关键词: Anabolism; Arthropods; Biochemistry; Biocompatible Materials; Biology; Chemistry; Claw; Computer Retrieval of Information on Scientific Projects Database; Deposition; Development; Fluorescence; Funding; Grant; Halogens; Image; Institution; Jaw; Metals; Microscopy; Range; Research; Research Personnel; Resolution; Resources; Source; Spatial Distribution; Spectrum Analysis; Sting Injury; Structure; Transition Elements; United States National Institutes of Health; absorption; beamline; research study; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to use x-ray absorption spectroscopy to characterize the metal-halogen biomaterials that are biosynthesized in the cuticular tools of most arthropods and a few other phyla. Maturation of these cuticular tools (fangs, stings, jaws, claws, etc.) involves the transport and deposition of transition metals (Mn, Fe, Cu, Zn) and halogens (Cl, Br, I) in amorphous structures that cannot be characterized by x-ray diffraction. We expect to uncover new biology, biochemistry, and materials chemistry in determining the structures and spatial distribution of these biomaterials during biosynthesis and maturation of these tools. Bulk XAS, followed by imaging and x-ray microscopy will allow detailed structural analysis. These experiments range from the straightforward (transition metal bulk XAS by fluorescence excitation) to the challenging (low-energy imaging at micron spatial resolution) that will take advantage of beamline developments for SPEAR3.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们建议使用 X 射线吸收光谱来表征大多数节肢动物和其他一些门的表皮工具中生物合成的金属卤素生物材料。这些角质工具（尖牙、刺、颚、爪等）的成熟涉及过渡金属（Mn、Fe、Cu、Zn）和卤素（Cl、Br、I）在无法表征的无定形结构中的传输和沉积通过X射线衍射。我们期望发现新的生物学、生物化学和材料化学，以确定这些生物材料在这些工具的生物合成和成熟过程中的结构和空间分布。批量 XAS、随后的成像和 X 射线显微镜将允许进行详细的结构分析。这些实验范围从简单的（通过荧光激发的过渡金属块体 XAS）到具有挑战性的（微米空间分辨率的低能量成像），这些实验将利用 SPEAR3 的光束线开发。