STRUCTURE-FUNCTION STUDIES OF CYSTEINE PROTEASES OF PARASITIC DISEASE AND ALLERG

寄生虫病和过敏症半胱氨酸蛋白酶的结构功能研究

• 批准号: 7597974
• 负责人: LINDA S BRINEN
• 金额: $ 0.26万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7597974
• 关键词: Allergic; Alzheimer' s Disease; Arthritis; Asthma; Bacterial Infections; Biological Process; Chagas Disease; Class; Computer Retrieval of Information on Scientific Projects Database; Cysteine Protease; Disease; Endopeptidases; Enzymes; Eukaryota; Eukaryotic Cell; Funding; Grant; Human; Hypersensitivity; Institution; Life Cycle Stages; Osteoporosis; Papain; Parasitic Diseases; Parasitic infection; Peptide Hydrolases; Play; Protozoa; Pyroglyphidae; Range; Research; Research Personnel; Resolution; Resources; Role; Source; Structure; Therapeutic; Trypanosoma cruzi; United States National Institutes of Health; antigen processing; cancer cell; cruzain; design; inhibitor/antagonist; member; programs; pyroglyphid; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cysteine proteases are present in nearly all groups of eukaryotes and play vital roles in a wide range of biological processes and diseases, including antigen processing, bacterial infection, arthritis, osteoporosis, Alzheimer¿s disease and cancer cell invasion. Several cysteine proteases of the papain superfamily are critical to the life-cycle progression of many pathogenic protozoa and therefore they represent potential targets for selective inhibitor design. It has also been determined that members of this same class of enzyme are required for human allergic and asthmatic response to the common house dust mite. High-resolution structural studies have provided valuable information for the design of anti-parasitic therapeutics that selectively regulate the cysteine protease cruzain, a key enzyme in the lifecycle of T. cruzi, the causative agent of Chagas¿ disease. The studies detailed in this program will expand our understanding and ability to regulate several new protease targets indicated in a variety of parasitic infections as well as proteases of dust mite allergy induced asthma.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 半胱氨酸蛋白酶在几乎所有的真核生物组中都呈现，并在各种生物学过程和疾病中起着至关重要的作用，包括抗原加工，细菌感染，关节炎，骨质疏松症，阿尔茨海默氏病和癌细胞入侵。木瓜蛋白酶超家族的几种半胱氨酸蛋白对于许多致病原生动物的生命周期进展至关重要，因此它们代表了选择性抑制剂设计的潜在靶标。还已经确定，人类过敏和哮喘反应对共同的房屋粉尘小ite需要的同类酶的成员是必需的。高分辨率的结构研究为抗寄生虫治疗剂的设计提供了有价值的信息，这些信息有选择地调节半胱氨酸蛋白酶cruzain，这是Cruzi的生命周期中的关键酶，T. cruzi是Chagas¿病的病因。该计划中详细介绍的研究将扩大我们的理解和能力，以调节多种寄生虫感染中指示的几种新蛋白质靶标以及粉尘螨过敏诱导哮喘的蛋白质。