STRUCTURES OF LIGNAN AND ISOFLAVONOID REDUCTASES, SEARCHING FOR THEIR MOLECULAR

木脂素和异黄酮还原酶的结构，寻找它们的分子

• 批准号: 7597896
• 负责人: CHULHEE KANG
• 金额: $ 0.42万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7597896
• 关键词: Accounting; Anabolism; Antifungal Agents; Antioxidants; Antiviral Agents; Biological; Carbon; Clinical Treatment; Communication; Computer Retrieval of Information on Scientific Projects Database; Cultured Cells; Diet; Enzymes; Funding; Goals; Grant; Incidence; Institution; Lignans; Lignin; Malignant Neoplasms; Molecular; Oxidoreductase; Pathway interactions; Physiological; Plants; Play; Preventive; Property; Regulation; Research; Research Personnel; Research Project Grants; Resolution; Resources; Role; Source; Structure; Structure-Activity Relationship; Tissues; United States National Institutes of Health; Vascular Plant; antimicrobial; base; interest; pathogen; success; Accounting; Anabolism; Antifungal Agents; Antioxidants; Antiviral Agents; Biological; Carbon; Clinical Treatment; Communication; Computer Retrieval of Information on Scientific Projects Database; Cultured Cells; Diet; Enzymes; Funding; Goals; Grant; Incidence; Institution; Lignans; Lignin; Malignant Neoplasms; Molecular; Oxidoreductase; Pathway interactions; Physiological; Plants; Play; Preventive; Property; Regulation; Research; Research Personnel; Research Project Grants; Resolution; Resources; Role; Source; Structure; Structure-Activity Relationship; Tissues; United States National Institutes of Health; Vascular Plant; antimicrobial; base; interest; pathogen; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lignins, lignans and isoflavonoids are major constituents of vascular plants and account for nearly 30% of the organic carbon circulating in the biosphere. This research project focuses on three enzymes that have critical roles in lignan and isoflavonoid biosynthesis. Lignans and isoflavonoids play important roles in plant defense and communication, helping hosts discriminate between biological pathogens and symbiotic non-pathogens. In addition to their physiological roles in plants, these compounds have pronounced antimicrobial, antifungal, antiviral, antioxidant and anticancer properties. Therefore, isoflavonoid and lignan are used as pharmacologicals, especially for the clinical treatment of various cancers. It is generally accepted that low cancer incidence in people with plant-based diets is due to the preventive effect of these lignans and isoflavonoids. For these reasons, there is considerable interest in making these compounds more generally available by defining and exploiting the lignan and isoflavonoid biosynthetic pathways. These approaches are seriously hampered by a lack of detailed information on the involving enzymes and by limited success in obtaining these compounds using tissue (or cell) culture. The goal of this project is to define the structure-function relationships of the critical enzymes in lignan and isoflavonoid biosynthesis through high-resolution x-ray structures. The information gained from these studies will be very useful for exploring the regulation of lignans and isoflavonoids for ecological plant protection, and industrial-scale regiospecific and stereospecific synthesis

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 木质素，木质植物和异黄素是血管植物的主要成分，占生物圈中循环的有机碳的近30％。该研究项目的重点是三种在木质烷和异黄酮生物合成中具有关键作用的酶。木叶党和异黄体在植物防御和交流中起着重要作用，有助于托管歧视生物病原体和共生非pathogens。 除了它们在植物中的生理作用外，这些化合物还具有明显的抗菌，抗真菌，抗病毒药，抗氧化剂和抗癌特性。因此，异黄酮和木质烷被用作药理学，尤其是用于各种癌症的临床治疗。人们普遍认为，基于植物性饮食的人的癌症发病率低是由于这些木脂蛋白和异黄体的预防作用。由于这些原因，通过定义和利用木质烷和异黄酮生物合成途径，使这些化合物更普遍地获得了人们的兴趣。缺乏有关酶的详细信息以及在使用组织（或细胞）培养获得这些化合物方面的有限成功的详细信息，从而严重阻碍了这些方法。该项目的目的是通过高分辨率X射线结构来定义木质烷和异黄酮生物合成中关键酶的结构 - 功能关系。从这些研究中获得的信息将非常有用，对于探索木质和异黄素的调节，以进行生态植物保护，以及工业规模的重新特异性和立体特异性合成