Udall Parkinson's Disease Research Center at Emory University

埃默里大学尤德尔帕金森病研究中心

基本信息

批准号：
9975930
负责人：
Thomas N Wichmann
金额：
$ 128.73万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-30 至 2022-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9975930
关键词：
Address Administrator Affect Algorithmic Analysis American Anatomy Animals Antiparkinson Agents Area Assisted Living Facilities Basal Ganglia Basic Science Behavior Behavior Control Brain Caregivers Cell Nucleus Cells Cerebral cortex Child Clinic Clinical Clinical Sciences Collaborations Communities Community Outreach Complement Data Analyses Deep Brain Stimulation Development Disease Education Education and Outreach Educational Activities Electron Microscopy Fostering Foundations Functional disorder Funding Future Teacher General Population Goals Grant High School Student Human Resources Immunohistochemistry Information Centers Institutes Institution Journals K-12 student Knowledge Light Link Mission Modeling Monkeys Morphology Motivation Movement Disorders Neurosciences Parkinson Disease Parkinsonian Disorders Patients Pattern Physiology Population Primates Recommendation Research Research Activity Research Personnel Research Project Grants Research Support Resources Rodent Role Scientist Series Services Slice Social Workers Societies Standardization Structure Students Synapses Thalamic structure Therapeutic Intervention Time Tissue Sample Training Training Programs Translational Research United States National Institutes of Health Universities Work age group biomedical referral center career career development clinical care clinical movement disorder clinical translation collaborative environment data sharing design experience experimental study in vivo innovation insight interest intervention effect laboratory experience motor control neuroregulation outreach outreach program programs relating to nervous system retiree science education side effect symposium virtual web site

项目摘要

The Morris K. Udall Parkinson's Disease Center of Excellence for Parkinson's Disease Research at Emory University is a collaborative research program in which electrophysiologists and anatomists study the pathophysiology of parkinsonism, and examine and optimize the effects of existing treatments for Parkinson's disease. The Center draws upon the proven ability of the basal ganglia research community at Emory to conduct translational research. Other Udall Center assets are its close ties to the clinical movement disorders group at Emory, and the availability of primates for research at the Yerkes National Primate Research Center at Emory University. Emory is strongly committed to the Udall Center's research, and supports the Center by funding pilot grants, invited speakers, and portions of its education and outreach programs. The Center consists of three tightly linked projects and two cores. The planned research will shed light on the poorly understood parkinsonism-related activity changes in thalamus and cortex which, in turn, will help us to better understand the pathophysiology of parkinsonism, and to optimize existing neuromodulation strategies and to develop new ones. Project 1 (led by Dr. Jaeger) will utilize brain slice and in vivo recordings in rodents, as well as a neural computational approach to develop mechanistic models of thalamocortical dysfunction in parkinsonism. Project 2 (Dr. Wichmann), will continue the exploration of thalamic and cortical abnormalities in parkinsonian monkeys, using selective activation and inactivation approaches which are designed to study corticothalamic, pallidothalamic and thalamocortical information transfer. Project 3 (Dr. Smith) will examine morphological changes in the thalamic and cortical microcircuitry in parkinsonian primates, a topic that is virtually unexplored at this time and of high relevance to the interpretation of data in the other projects. All projects will be supported by an Administrative Core (Dr. Wichmann, PI; Dr. DeLong, Co-I, Dr. Smith, Co-I, Ms Holbrook, administrator), and by an Anatomy and Behavior Core (Dr. Galvan) which will provide immunohistochemistry and electron microscopy services to all of the center projects, and standardized MPTP treatment and quantification of parkinsonism to the primate experiments in Projects 2 and 3. In addition to pursuing its research mission (Aim 1), the Center will help junior scientists to develop their career in Parkinson's disease research (Aim 2), and will engage in extensive outreach efforts, aimed at communicating the Center's (and Udall Center network) research findings to the public (Aim 3), reaching all age groups and background levels, ranging from K-12 children to retirees in assisted living facilities. As part of the outreach agenda, the center plans to organize annual symposia for patients and their caregivers. The center will be generously supported by the University. These internal support funds will help the Center to fund some of its education and outreach missions, as well as its pilot grant program, designed to expand Parkinson's disease research at Emory University.

埃默里大学莫里斯·尤德尔帕金森病研究卓越中心是一个合作研究项目，电生理学家和解剖学家研究帕金森病的病理生理学，并检查和优化现有帕金森病治疗方法的效果。该中心利用埃默里大学基底神经节研究界经过验证的能力进行转化研究。尤德尔中心的其他资产包括与埃默里大学临床运动障碍小组的密切联系，以及埃默里大学耶克斯国家灵长类动物研究中心可提供灵长类动物进行研究。埃默里大学坚定地致力于尤德尔中心的研究，并通过资助试点拨款、特邀演讲者以及部分教育和外展项目来支持该中心。该中心由三个紧密相连的项目和两个核心组成。计划中的研究将揭示丘脑和皮质中与帕金森病相关的活动变化知之甚少，这反过来又将帮助我们更好地了解帕金森病的病理生理学，优化现有的神经调节策略并开发新的策略。项目 1（由 Jaeger 博士领导）将利用啮齿动物的脑切片和体内记录以及神经计算方法来开发帕金森病丘脑皮质功能障碍的机制模型。项目 2（Wichmann 博士）将继续探索帕金森猴的丘脑和皮质异常，采用选择性激活和失活方法，旨在研究皮质丘脑、苍白丘脑和丘脑皮质信息传递。项目 3（史密斯博士）将检查帕金森灵长类动物的丘脑和皮质微电路的形态变化，这个主题目前实际上尚未被探索，并且与其他项目中数据的解释高度相关。所有项目都将得到行政核心（Wichmann 博士，PI；DeLong 博士，Co-I，Smith 博士，Co-I，Holbrook 女士，管理员）以及解剖和行为核心（Galvan 博士）的支持将为中心的所有项目提供免疫组织化学和电子显微镜服务，并为项目 2 和 3 中的灵长类动物实验提供标准化 MPTP 治疗和帕金森病定量服务。（目标 1），该中心将帮助初级科学家发展帕金森病研究的职业生涯（目标 2），并将开展广泛的外展工作，旨在向公众传达该中心（和尤德尔中心网络）的研究成果（目标3)，覆盖所有年龄组和背景水平，从 K-12 儿童到辅助生活设施中的退休人员。作为外展议程的一部分，该中心计划为患者及其护理人员组织年度研讨会。该中心将得到大学的慷慨支持。这些内部支持资金将帮助该中心资助其一些教育和外展任务，以及旨在扩大埃默里大学帕金森病研究的试点拨款计划。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Reply to: "Starting from Scratch-Basal Ganglia Pathophysiology".

回复：《从零开始——基底节病理生理学》。

DOI：
发表时间：
2020
期刊：
影响因子：
0
作者：
Wichmann; Thomas
通讯作者：
Thomas

Automated deep brain stimulation programming with safety constraints for tremor suppression in patients with Parkinson's disease and essential tremor.

具有安全约束的自动深部脑刺激编程，可抑制帕金森病和特发性震颤患者的震颤。

DOI：
发表时间：
2022-08-18
期刊：
影响因子：
0
作者：
Sarikhani, Parisa;Ferleger, Benjamin;Mitchell, Kyle;Ostrem, Jill;Herron, Jeffrey;Mahmoudi, Babak;Miocinovic, Svjetlana
通讯作者：
Miocinovic, Svjetlana

Meta-Bayesian Optimization for Deep Brain Stimulation.

深部脑刺激的元贝叶斯优化。