Role and Mechanism of Hearing Impairment in Cognitive Decline and Dementia

听力障碍在认知衰退和痴呆中的作用和机制

• 批准号: 9974449
• 负责人: JENNIFER Anne DEAL
• 金额: $ 12.94万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9974449
• 关键词: Acoustic Stimulation; Address; Affect; Age; Aging; Air; Alzheimer' s Disease; Alzheimer' s disease brain; Amyloid beta-Protein; Ankle; Applications Grants; Appointment; Area; Atherosclerosis Risk in Communities; Attenuated; Audiology; Auditory; Award; Baltimore; Biological Markers; Blood Vessels; Brain; Brain imaging; Brain region; Cerebrovascular Disorders; Cerebrum; Clinic; Clinical; Clinical Research; Cognitive; Cognitive aging; Collection; Data; Data Analyses; Dementia; Development; Diabetes Mellitus; Diagnosis; Disease; Disease Marker; Educational workshop; Elderly; Epidemiologist; Epidemiology; Five-Year Plans; Functional disorder; Funding; Fundus photography; Future; Goals; Head and Neck Surgery; Health; Healthcare; Hearing; Hearing Aids; Hearing Tests; Hypertension; Image; Impaired cognition; Individual; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Knowledge; Lacunar Infarctions; Lead; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mentors; Methods; Obesity; Observational Study; Otolaryngology; Participant; Pathology; Pathway interactions; Peripheral; Population Study; Positioning Attribute; Positron-Emission Tomography; Process; Publications; Publishing; Pure-Tone Audiometry; Reporting; Research; Research Personnel; Resources; Retina; Risk Factors; Role; Science; Scientist; Signal Transduction; Smoking; Structure; Techniques; Testing; Time; Training; Training Programs; United States National Academy of Sciences; United States National Institutes of Health; Universities; White Matter Hyperintensity; abeta deposition; adjudicate; adverse outcome; aging brain; auditory processing; aural rehabilitation; base; brain volume; career; cerebrovascular; clinical translation; cognitive function; cognitive neuroscience; cohort; disability; empowered; epidemiology study; healthy aging; hearing impairment; improved; indexing; informal learning; insight; medical schools; middle age; modifiable risk; mortality; neurocognitive test; neuroimaging; neuron loss; prevent; prospective; skills; tau Proteins; vascular factor; vascular risk factor; β-amyloid burden

ABSTRACT Jennifer A. Deal is an epidemiologist and gerontologist, with a position as Assistant Scientist in the Department of Epidemiology, Johns Hopkins Bloomberg School of Medicine and a secondary appointment in the Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine. She seeks a mentored career development award to fill knowledge gaps in her current training so that her research can successfully bridge the diverse fields of cognitive aging, audiology, otolaryngology, epidemiology and cognitive neuroscience in order to improve the health of older adults. The primary component of the training proposal includes a comprehensive five-year plan of formal and informal instruction in the acquisition, processing and analysis of neuroimaging data (structural MRI and PiB PET) in large population-based studies. The PI will also augment current knowledge about the collection and analysis of hearing data in epidemiologic studies with additional training in the clinical aspects and pathophysiology of hearing impairment. The training program consists of didactic coursework and seminars, clinic observations, and mentored research by an established and diverse team of experts. Short-term career goals include completion and dissemination of high-quality mentored research through publications and presentations and application for independent R01 funding beginning in the fourth year of the award period. Long-term career goals are to be an independent investigator in the area of aging and cognitive decline and dementia, with expertise in hearing impairment. The specific aims of the proposed research are to quantify the independent association of HI incident dementia and with domain-specific cognitive decline in three well-characterized prospective observational studies, to investigate the relationship of HI with changes in brain volume over time (both in regions related to Alzheimer's disease and to auditory processing), and to quantify the role of vascular factors in the development of HI. Completion of the proposed aims will elucidate the role and mechanism of hearing impairment in dementia and domain-specific cognitive decline, providing possible targets for future clinical research with the potential to inform efforts to prevent these adverse outcomes in older adults.

抽象的 Jennifer A. Deal 是一位流行病学家和老年学家，担任该部门的助理科学家 约翰·霍普金斯大学彭博医学院流行病学博士，并在 约翰霍普金斯大学医学院耳鼻咽喉头颈外科系。她寻找一个 指导职业发展奖，以填补她当前培训中的知识空白，以便她的研究能够 成功地连接了认知衰老、听力学、耳鼻喉科、流行病学和认知等不同领域 神经科学，以改善老年人的健康。 培训提案的主要组成部分包括正式和非正式的全面五年计划 指导神经影像数据（结构 MRI 和 PiB PET）的采集、处理和分析 以大规模人群为基础的研究。 PI 还将增强有关收集和分析的当前知识 流行病学研究中的听力数据以及临床方面和病理生理学方面的额外培训 听力障碍。培训计划包括教学课程和研讨会、临床观察、 并由成熟的多元化专家团队指导研究。短期职业目标包括 通过出版物和演示完成和传播高质量的指导研究 从奖励期的第四年开始申请独立的 R01 资助。长期职业生涯 目标是成为衰老、认知衰退和痴呆领域的独立研究者， 听力障碍方面的专业知识。 拟议研究的具体目的是量化 HI 事件痴呆的独立关联 在三项特征明确的前瞻性观察研究中，随着特定领域的认知能力下降， 研究 HI 与脑容量随时间变化的关系（均与阿尔茨海默病相关的区域） 疾病和听觉处理），并量化血管因素在 HI 发展中的作用。 完成拟议目标将阐明听力障碍在痴呆症和痴呆症中的作用和机制 特定领域的认知能力下降，为未来的临床研究提供了可能的目标 为老年人预防这些不良后果的努力提供信息。