Biomarkers in Huntington's disease: Targeted and survey Metabolomics

亨廷顿病的生物标志物：靶向代谢组学调查

• 批准号: 7434819
• 负责人: WAYNE R MATSON
• 金额: $ 15.23万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-19 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7434819
• 关键词: 3-nitrotyrosine; 4 hydroxynonenal; 8-hydroxyguanine; 8-hydroxyguanosine; Acetylation; Animals; Automobile Driving; Binding; Biochemical; Biological Markers; Blood; Brain; Cellular Structures; Clinical; Clinical Trials; Coenzyme Q10; Creatine; DNA; Data; Databases; Deoxyguanosine; Depth; Development; Diagnostic; Disease; End Point; Equipment and supply inventories; Erythrocytes; Failure; Feedback; Free Radicals; Gene Expression Profile; Gene Mutation; Genome; Glutamic Acid; Glutamine; Glutathione; Glutathione Disulfide; Guanine; Heterogeneity; Histocompatibility Testing; Histones; Homeostasis; Human; Huntington Disease; Huntington gene; Hypoxanthine; Hypoxanthines; Individual; Indoles; Intervention; Kynurenic Acid; Lipids; Lysine; Measurement; Measures; Methylation; Modeling; Monitor; Mus; Pathway interactions; Peripheral; Phenotype; Plasma; Principal Investigator; Proteins; Proteome; RNA; Sampling; Serotonin; Staging; Statistically Significant; Surveys; Symptoms; Therapeutic; Therapeutic Intervention; Time; Urine; Whole Blood; Work; Xanthines; design; excitotoxicity; human subject; indole; metabolomics; mouse model; neuroimaging; plasma protein fraction; programs; protein aggregation; response; small molecule; xanthine