Neurobiological characteristics, parent-child relationships, and conduct problems in adolescence: A longitudinal multimodal neuroimaging study

青春期的神经生物学特征、亲子关系和行为问题：一项纵向多模式神经影像研究

• 批准号: 9924570
• 负责人: Yu Gao
• 金额: $ 39.25万
• 依托单位: BROOKLYN COLLEGE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9924570
• 关键词: Adolescence; Adolescent; Adult; Age; Aggressive behavior; Antisocial Personality Disorder; Anxiety; BRAIN initiative; Behavior; Behavioral; Biological; Biological Markers; Brain; Brain imaging; Buffers; Characteristics; Child; Childhood; Clinical assessments; Conduct Disorder; Corpus striatum structure; Cues; Data; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Disruptive Behavior Disorder; Educational process of instructing; Emotional; Environment; Environmental Risk Factor; Etiology; Event; Family; Fibrinogen; Foundations; Fright; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Growth; Human Resources; Imaging Techniques; Impairment; Individual; Individual Differences; Intervention; Knowledge; Learning; Magnetic Resonance Imaging; Measures; Methodology; Mission; Modeling; Modification; Neural Pathways; Neurobiology; Outcome Assessment; Parent-Child Relations; Participant; Phase; Prevention; Problem behavior; Process; Psyche structure; Psychopathology; Psychophysiology; Psychosocial Factor; Public Health; Punishment; Research; Research Domain Criteria; Rewards; Risk; Risk Factors; Risk-Taking; Role; Structure; Symptoms; Systems Development; Testing; Time; United States National Institutes of Health; Youth; anti social; antisocial behavior; behavioral outcome; biobehavior; cohort; conditioning; conduct problem; criminal behavior; criminal offending; design; experience; follow-up; frontal lobe; imaging approach; improved; longitudinal analysis; multilevel analysis; multimodality; neighborhood safety; neural patterning; neurobehavioral; neuroimaging; participant retention; preadolescence; prenatal; prospective; psychosocial; recruit; relating to nervous system; social; white matter

Project Abstract Conduct problems, which include aggression and rule-breaking behavior, in children and adolescence are significant risk factors for future criminal behavior. One possible mechanism involves atypical development of brain structure and/or function implicated in reward and punishment processing in at-risk individuals. Reduced reward sensitivity may drive maladaptive reward seeking behavior via attempts to “normalize” reward-related neural reactivity, and may result in compromised learning of appropriate behaviors. On the other hand, weakened punishment sensitivity may increase the risk of antisocial behavior because the individual failing to form associations between cues and negative consequence does not have anxiety and anticipatory fear whenever contemplating the engagement in an antisocial act. However, most of the prior research is cross-sectional. The objective of this study is to understand the origin and development of conduct problems from a longitudinal perspective, by repeatedly assessing the risk factors (impaired reward/ punishment processing) from childhood to adolescence, identifying the vulnerable neural substrates underpinning these processes, and determining the modulating effects of environmental factors (i.e., parent- child relationship). Capitalizing on an existing cohort whose neurobehavioral measures were objectively assessed at 8-9 years and again at 9-10 years (SC2HD076044, PI: Gao), the current project proposes to re-assess the participants annually starting at 14-15 years for three years. We will assess biological and social risk factors using a battery identical (with age-appropriate modifications) to the one used in prior studies, as well as age- appropriate psychosocial risk factor and behavioral outcome assessments. Moreover, I will build upon my current SC3 funding (SC3GM118233, PI: Gao) and utilize a longitudinal multi-modal Magnetic Resonance Imaging (MRI) approach to study the changes in function of the circuitry implicated in reward/punishment processing (using fMRI) and the white-matter connections (using Diffusion Tensor Imaging) across a 1.5-year period from the same cohort. My central hypotheses are that atypical development of reward/punishment processing from childhood to adolescence will be associated with more conduct problems, and that positive parent-child relationship will buffer the effect of neural vulnerability on the development of behavioral problems. Completion of this project will advance the mission of the NIH BRAIN Initiative to “understand the circuits and patterns of neural activity that give rise to mental experience and behavior”. Understanding the neural and autonomic mechanisms that contribute to the reward/punishment processing related to conduct problems has the potential to uncover underlying psychopathological processes involved in the development of these problems, and will improve etiological models that provide the foundation for intervention and treatment.

项目摘要 儿童和青少年的行为问题，包括攻击性和违反规则的行为 是未来犯罪行为的重要风险因素，一种可能的机制涉及非典型发展。 与高危个体的奖励和惩罚处理有关的大脑结构和/或功能。 奖励敏感性降低可能会通过尝试“正常化”来驱动适应不良的奖励寻求行为 奖励相关的神经反应，并可能导致适当行为的学习受到影响。 另一方面，惩罚敏感性减弱可能会增加反社会行为的风险，因为 未能在暗示和负面后果之间建立联系的个体不会有焦虑和 每当考虑参与反社会行为时，就会出现预期性恐惧，但大多数情况下都是如此。 本研究的目的是了解行为的起源和发展。 通过反复评估风险因素（奖励受损/ 惩罚处理）从童年到青春期，识别脆弱的神经基质 支持这些过程，并确定环境因素（即父母的影响）的调节作用 子女关系）。 利用现有队列，其神经行为指标在 8-9 点进行了客观评估 9-10 年一次又一次（SC2HD076044，PI：高），目前的项目建议重新评估 从 14-15 岁开始，我们将每年评估生物和社会风险因素，持续三年。 使用与之前研究中使用的电池相同（经过适合年龄的修改）的电池，以及年龄 此外，我将根据我的经验进行适当的社会心理风险因素和行为结果评估。 目前的 SC3 资金（SC3GM118233，PI：高）并利用纵向多模态磁共振 成像 (MRI) 方法研究奖励/惩罚中涉及的电路功能的变化 1.5 年的处理（使用功能磁共振成像）和白质连接（使用扩散张量成像） 我的中心假设是奖励/惩罚的非典型发展。 从童年到青春期的过程将与更多的行为问题相关，并且积极的 亲子关系会缓冲神经脆弱性对行为问题发展的影响。 该项目的完成将推进 NIH BRAIN Initiative 的使命，即“理解电路和 产生心理体验和行为的神经活动模式”。 有助于与行为问题相关的奖励/惩罚处理的自主机制 揭示这些发展所涉及的潜在心理病理过程的潜力 问题，并将改进病因学模型，为干预和治疗提供基础。