Basic Mechanisms in Aging and Age Related Disease

衰老和年龄相关疾病的基本机制

• 批准号: 7476007
• 负责人: Dale E. Bredesen
• 金额: $ 7.5万
• 依托单位: BUCK INSTITUTE FOR RESEARCH ON AGING
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476007
• 关键词: Advisory Committees; Age; Aging; Aging-Related Process; Alzheimer' s Disease; Animal Experimentation; Animal Model; Area; Arthritis; Arts; Award; Basic Science; Biochemistry; Bioinformatics; Biology of Aging; Biomedical Research; British Columbia; Caenorhabditis elegans; Caloric Restriction; Chemicals; Clinical; Clinical Services; Collaborations; Communicable Diseases; Complementary DNA; Computer software; Contract Services; Coupling; Data; Development; Discipline; Disease; Economic Burden; Educational process of instructing; Endocrine; Ensure; Environment; Equipment; Extramural Activities; Family; Fostering; Frequencies; Functional Imaging; Functional disorder; Funding; Future; Genetic; Genomics; Goals; Heart; Human Resources; Image; Imaging Techniques; Imaging technology; Individual; Injury; Institutes; Institution; Interdisciplinary Study; Investigation; Investigator-Initiated Research; Investments; Knock-out; Laboratories; Life; Longevity; Malignant Neoplasms; Mass Spectrum Analysis; Medical; Methodology; Methods; Microarray Analysis; Mission; Modeling; Morphology; Mus; NCI Scholars Program; Neurobiology; Neurodegenerative Disorders; Office of Administrative Management; Oligonucleotides; Operative Surgical Procedures; Parkinson Disease; Participant; Pathway interactions; Pilot Projects; Pliability; Politics; Post-Translational Protein Processing; Private Sector; Procedures; Process; Production; Proteins; Proteomics; Publications; Range; Reagent; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Resources; Science; Services; Shock; Signal Transduction; Societies; Stroke; System; Technology; Time; Training; Training Programs; Transgenic Animals; Transgenic Organisms; Translating; Underrepresented Minority; United States; United States National Institutes of Health; Universities; Update; Upper arm; Washington; Wisconsin; age related; animal care; base; college; health economics; high school; instrumentation; knockout gene; medical schools; multidisciplinary; new technology; novel strategies; post-doctoral training; prevent; programs; protein protein interaction; research and development; structural biology; success; symposium; university student

DESCRIPTION (provided by applicant): The Buck Institute for Age Research is the only free-standing institute in the United States that is devoted exclusively to basic research on the biology of aging and age-related diseases. Its intensive, interdisciplinary, institution-wide approach to aging research represents a new model, distinct from the traditional university-based approach in which the study of aging is one of numerous disciplines, spread throughout an institution, and competing with other disciplines for scarce scientific resources. In the five years since the Buck Institute began operation, it has made a substantial investment in and commitment to aging research. In the process, Buck Institute investigators have made important contributions to research on the biology of aging and age-related diseases, including Alzheimer's disease, Parkinson's disease, stroke and cancer, and the Institute has established itself as a major aging research center. We believe that the Buck Institute is ideally suited to fulfill the goal of the Nathan Shock Centers of Excellence in Basic Biology of Aging program - to enhance the ability of institutions with well-developed research programs in basic research on aging to utilize state-of-the-art research resources and provide the strongest environment for the conduct of research on aging by: (a) enhancing the quality of research in the basic biology of aging (b) facilitating the planning and coordination of aging research activities (c) providing support and a suitable environment for investigators new to aging research and (d) developing potential regional or national resource centers. To achieve these objectives, we propose to establish a Shock Center at the Buck Institute with the following Cores: An Animal/Transgenics Core offering animal care and procedures and transgenic/knockout production, an Imaging Core in which existing morphology resources will be supplemented with functional imaging technology, a Genomics Core that will produce cDNA and oligo microarray chips and offer microarray analysis services, and a Proteomics Core using mass spectrometry and new chemical methods to identify posttranslational modifications and protein-protein interaction networks associated with aging and age-related diseases. Finally, a Research Development Core will foster the development of investigators and projects in aging research through postdoctoral training programs, Research Development Research Seminars, Pilot Project awards to junior investigators and investigators new to the aging field, and a Summer Scholars program for high school and college students from underrepresented minority backgrounds.

描述（由申请人提供）：巴克年龄研究所是美国唯一一家专门致力于衰老生物学和与年龄相关疾病的基础研究的独立研究所。其密集、跨学科、全机构的老龄化研究方法代表了一种新模式，与传统的以大学为基础的方法不同，在传统的大学方法中，老龄化研究是众多学科之一，遍布整个机构，并与其他学科争夺稀缺的科学资源。资源。巴克研究所成立五年来，对衰老研究进行了大量投资和承诺。在此过程中，巴克研究所的研究人员为衰老生物学和与年龄相关的疾病（包括阿尔茨海默病、帕金森病、中风和癌症）的生物学研究做出了重要贡献，该研究所已将自己打造成一个主要的衰老研究中心。我们相信，巴克研究所非常适合实现内森休克衰老基础生物学卓越中心项目的目标，即提高在衰老基础研究方面拥有完善研究项目的机构利用最新状态的能力。提供最先进的研究资源，并通过以下方式为开展老龄化研究提供最强有力的环境： (a) 提高老龄化基础生物学的研究质量 (b) 促进老龄化研究活动的规划和协调 (c) 提供支持为刚接触衰老研究的研究人员提供合适的环境(d) 发展潜在的区域或国家资源中心。为了实现这些目标，我们建议在巴克研究所建立一个休克中心，具有以下核心：动物/转基因核心，提供动物护理和程序以及转基因/基因敲除生产；成像核心，其中现有的形态学资源将得到功能性的补充。成像技术、基因组学核心将生产 cDNA 和寡核苷酸微阵列芯片并提供微阵列分析服务，以及蛋白质组学核心，使用质谱和新化学方法来识别与衰老和衰老相关的翻译后修饰和蛋白质-蛋白质相互作用网络。与年龄有关的疾病。最后，研究发展核心将通过博士后培训计划、研究发展研究研讨会、向初级研究人员和新进入老龄化领域的研究人员提供试点项目奖励，以及针对高中和高中生的暑期学者计划，促进老龄化研究的研究人员和项目的发展。来自少数族裔背景的大学生。