Treatment of Emotional Disorders in Adolescence

青春期情绪障碍的治疗

基本信息

批准号：
7645852
负责人：
JILL EHRENREICH-MAY
金额：
$ 16.45万
依托单位：
UNIVERSITY OF MIAMI CORAL GABLES
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7645852
关键词：
Address Adherence Adolescence Adolescent Adult Affect Aftercare Agoraphobia Alcohol or Other Drugs use Anxiety Anxiety Disorders Area Arts Behavior Biological Child Childhood Chronic Clinical Clinical Research Communities Comorbidity Depressive disorder Development Development Plans Diagnostic Disease Disease remission Doctor of Philosophy Dysthymic Disorder Effectiveness Emotional disorder Emotions Evaluation Exhibits Family Feedback Feeling suicidal Female Fostering Future Generalized Anxiety Disorder Goals Hand Intervention Intervention Studies Investigation K-Series Research Career Programs Knowledge Left Life Literature Maintenance Major Depressive Disorder Manuals Measures Mental disorders Mentored Patient-Oriented Research Career Development Award Mentors Monitor Mood Disorders National Institute of Mental Health Obsessive-Compulsive Disorder Outcome Panic Disorder Parents Participant Patient Self-Report Perception Phase Pilot Projects Population Post-Traumatic Stress Disorders Procedures Protocols documentation Provider Psychopathology Psychotherapy Quality of life Questionnaires Randomized Clinical Trials Relative (related person)Reporting Research Research Personnel Research Project Grants Risk Sampling Scientist Separation Anxiety Disorder Severities Social Adjustment Social Phobia Source Specific qualifier value Structure Students Suicide Symptoms Training Treatment Effectiveness Treatment Efficacy Treatment Protocols Waiting Lists Work Youth aged agoraphobia without history of panic disorder base career career development clinical practice clinically significant community consultation community setting depression depressive symptoms effectiveness research effectiveness trial emotion regulation experience high risk improved innovation intervention program knowledge base meetings novel patient oriented patient oriented research programs psychologic satisfaction skills theories therapy development treatment effect treatment program

项目摘要

DESCRIPTION (provided by applicant): This application is a request for a Mentored Patient-Oriented Research Career Development Award (K23) from the NIMH to foster the academic career development of the applicant, Jill T. Ehrenreich, Ph.D. The applicant will work with her primary mentor, Dr. David Barlow, her co-mentor, Dr. Wendy Silverman, and expert consultants, Dr. Laura Mufson, Dr. John Weisz, Dr. James Gross, Dr. Richard Lerner, and Dr. Timothy Brown, to develop expertise in conducting clinical research to establish innovative and efficacious interventions for adolescents with emotional disorders. In a career development plan spanning five years, the applicant has delineated short-term and long-term goals to prepare her for a patient-oriented research career. Short-term goals include obtaining didactic training and mentoring in several "core" areas that have been chosen to deepen her existing skills and to expand her skills into new areas. The applicant's long-term goals are to develop a programmatic line of research that is focused on developing innovative treatments for anxiety disorders in childhood and adolescence, and their most commonly comorbid conditions, as well as to launch a highly productive career as a clinical scientist. A formal research plan is proposed to investigate emotional disorders in adolescence, focusing specifically on anxiety disorders and unipolar mood disorders. Despite theory and research that suggests these disorders may share common biological and psychological vulnerabilities, demonstrate high comorbidity with one another, and evidence a potentially chronic impact on development, there have been few treatment studies investigating the efficacy of a single protocol with the applicability to treat this array of conditions in adolescence. The primary goal of the proposed research plan is to develop and apply a novel treatment for adolescents with emotional disorders, based on efficacious treatments for anxiety and depression in youth and an existent intervention for adults that unites fundamental treatment components appropriate for intervention with wide range of emotional disorders. The main goals of this project are: (1) to create a new treatment, entitled Adolescent Depression and Anxiety Protocol Treatment (ADAPT), for adolescents exhibiting a range of emotional disorders; (2) to conduct a small open trial using ADAPT with 15 adolescents evidencing anxiety and/or unipolar mood disorders; and, (3) to establish an initial effect size for the ADAPT program in a pilot study with 60 adolescents with anxiety and/or unipolar mood disorders and to assess maintenance of change at 3 and 6 months following treatment. The resulting treatment may have a far-reaching impact via dissemination to community providers treating adolescents with anxiety and depression by virtue of its relative consistency in format, combined with its breadth of application.

描述（由申请人提供）：此申请是从NIMH申请指导的注重患者研究职业发展奖（K23），以促进申请人的学术职业发展，Jill T. Ehrenreich博士。申请人将与她的主要导师David Barlow博士，她的同事Wendy Silverman博士以及专家顾问，Laura Mufson博士，John Weisz博士，John Weisz博士，James Gross博士，Richard Lerner博士和Timothy Brown博士，旨在开发用于建立创新和有效干预的临床研究方面的专业知识，以建立具有情感性情感的创新干预措施。在五年的职业发展计划中，申请人介绍了短期和长期目标，为她准备以患者为导向的研究职业做好准备。短期目标包括在几个“核心”领域中获得教学培训和指导，这些领域被选为加深她的现有技能并将其技能扩展到新领域。申请人的长期目标是开发一项计划研究线，该研究重点是开发童年和青春期焦虑症的创新治疗，及其最常见的合并症，以及作为临床科学家的高产职业。提出了一项正式的研究计划，以调查青春期情绪障碍，专门针对焦虑症和单极情绪障碍。尽管理论和研究表明这些疾病可能具有共同的生物学和心理脆弱性，但彼此之间表现出很高的合并症，并证明了对发展的潜在长期影响，但很少有治疗研究研究单一方案的疗效，具有适用性，可以在青春期治疗这一条件。拟议的研究计划的主要目标是基于对年轻人的焦虑和抑郁症的有效治疗，以及对成年人的焦虑和抑郁症的有效治疗，并为成年人提供了一种新的治疗方法，并为成年人进行了干预，这些干预措施将适合于各种情感障碍干预的基本治疗成分结合在一起。该项目的主要目标是：（1）为表现出一系列情绪障碍的青少年创建一种新的治疗方法，标题为“青少年抑郁和焦虑方案治疗（适应）”；（2）使用15位青少年适应焦虑和/或单极情绪障碍的小型开放试验；（3）在一项试点研究中建立自适应计划的初始效果大小，其中60名患有焦虑和/或单极情绪障碍的青少年，并评估治疗后3和6个月的变化维持。由此产生的治疗方法可能会通过向社区提供者传播对社区提供者的焦虑和抑郁症的相对一致性，并加上其应用的广度，从而产生深远的影响。