Metal-Catalyzed Methods for Organic Synthesis

金属催化有机合成方法

• 批准号: 9923326
• 负责人: STEPHEN L BUCHWALD
• 金额: $ 5.7万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9923326
• 关键词: Agrochemicals; Alkenes; Biological; Carbon; Catalysis; Complex; Copper; Electronics; Metals; Methods; Natural Products; Nitrogen; Organic Synthesis; Pharmacologic Substance; Process; Reaction; Structure; Techniques; Work; benzimidazole; design; interest; scaffold; sensor

Project Summary/Abstract: We are interested in developing general and useful new methods for the formation of carbon- carbon and carbon-heteroatom bonds. Utilizing copper-catalysis we will focus on the direct asymmetric functionalization of benzimidazoles with unactivated olefins. Substituted benzimidazoles are ubiquitous scaffolds in pharmaceuticals, natural products, agrochemicals, electronics and sensors. New methods would allow access to quickly and efficiently build a wide-range of complex molecules. Optimization of reaction conditions, exploration of substrate scope and mechanistic studies will be conducted to aid us in the discovery and utility of this work.

项目摘要/摘要： 我们有兴趣开发通用且有用的新方法来形成碳 碳和碳-杂原子键。利用铜催化，我们将重点关注直接 苯并咪唑与未活化烯烃的不对称官能化。替补 苯并咪唑是药物、天然产物、农用化学品中普遍存在的支架， 电子产品和传感器。新方法将允许快速有效地构建 范围广泛的复杂分子。反应条件优化、底物探索 将进行范围和机制研究，以帮助我们发现和利用这一点 工作。