ATN 025: HEPATITIS B VACCINATION IN YOUTHS

ATN 025：青少年乙型肝炎疫苗接种

• 批准号: 7608358
• 负责人: LAWRENCE James D'ANGELO
• 金额: $ 0.81万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608358
• 关键词: Antibodies; Computer Retrieval of Information on Scientific Projects Database; Dose; Funding; Gender; Grant; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B Vaccination; Institution; Outcome; Phase; Randomized; Research; Research Personnel; Resources; Safety; Single-Blind Study; Source; Surface; Treatment Protocols; United States National Institutes of Health; Upper arm; Vaccination; Youth

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a Phase II, randomized, single-blinded trial of two Hepatitis B immunization regimens in 150 HIV-negative, Hepatitis B core antibody, Hepatitis B surface antigen, and surface antibody negative youth. The randomization will be restricted, so that the percentage of either gender does not exceed 60% of the subjects on either of the two arms. Vaccinations will be given in a two-dose refimer at 0 and six months and the primary outcome will be seroresponsiveness one month after the six-month dose. Safety and tolerability will also be assessed.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这是150种HIV阴性，乙型肝炎核心抗体，乙型肝炎表面抗原和表面抗体阴性青年的II期，随机，单盲试验。 随机分组将受到限制，因此两个性别的性别的百分比不超过两个臂中任何一个受试者的60％。 疫苗接种将在0和六个月的两剂重二剂中进行，主要结果将是六个月剂量后一个月的静止措施。 安全性和耐受性也将进行评估。