COBRE: MECHANISMS OF PLASTICITY & REPAIR AFTER SCI D: BEHAV & ELECTROPHYS CORE

COBRE：可塑性机制

• 批准号: 7609760
• 负责人: David SK Magnuson
• 金额: $ 16.92万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609760
• 关键词: Action Potentials; Animals; Axon; Behavior; Behavior assessment; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Cutaneous; Development; Electrophysiology (science); Funding; Grant; Hair; Hindlimb; Hyperalgesia; Hypersensitivity; Injury; Institution; Joints; Lateral; Limb structure; Locomotion; Magnetism; Measures; Motor Evoked Potentials; Mus; Pathway interactions; Purpose; Rattus; Reflex action; Research; Research Personnel; Resources; Sensorimotor functions; Sensory; Somatosensory Evoked Potentials; Source; Spinal Cord; Standards of Weights and Measures; Swimming; Testing; United States National Institutes of Health; Walking; kinematics; novel; repaired; tool; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Electrophysiology and Behavior CORE (CORE D) is to provide a battery of standard tests to assess the function of animals and their spinal cords after injury and treatment, and to facilitate the development of more specialized tests that may be needed for the COBRE projects. The CORE will provide the following tests: 1. Transcranial magnetic motor evoked potentials (tcMMEPs) to assess action potential conduction in descending axons located in the ventrolateral funiculus in rats and mice. 2. Somatosensory evoked potentials (SSEPs) to assess ascending primary sensory pathways (rats only). 3. Magnetic interenlargement reflexes (MIERs) to assess conduction in ascending propriospinal axons located in the lateral white matter (rats only). 4. Open Field Locomotor Scale (BBB) to assess hindlimb function during overground locomotioin in rats and the Basso Mouse Scale (BMS) for mice. 5. A grid-walking test to assess sensorimotor function. 6. The Louisville Swimming Scale (LSS; rats only) to assess hindlimb function during swimming. 7. Hindlimb kinematics during overground locomotion and swimming for rats and mice using joint angle, limb excursion and step cycle duration as primary measures. 8. The Hargreave's test to assess cutaneous hyperalgesia. 9. Electro von Frey hairs to assess mechano-hypersensitivity after injury. In addition the CORE will pursue the development of novel electrophysiological and behavioral assessment tools as needed by specific projects within the COBRE laboratires.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 电生理学和行为核心（核心D）的目的是提供一系列标准测试，以评估受伤和治疗后动物及其脊髓的功能，并促进毛绒项目可能需要的更专业测试的开发。 核心将提供以下测试：1。经颅磁力诱发电位（TCMMEPS），以评估位于大鼠和小鼠腹外侧funiculus的降轴突中的动作电势传导。 2。体感诱发电位（SSEP），以评估上升的一级感觉途径（仅大鼠）。 3。磁间反射（miers），以评估位于侧白质（仅大鼠）中上升的前脊髓轴突的传导。 4。开放式运动量表（BBB），以评估大鼠的地面机关素期间的后肢功能和小鼠的巴索小鼠量表（BMS）。 5。进行网格步行测试，以评估感觉运动功能。 6。路易斯维尔游泳量表（仅LSS；仅大鼠）在游泳过程中评估后肢功能。 7。在地面运动过程中，后肢运动学在大鼠和小鼠的游泳过程中使用关节角度，肢体偏移和阶梯循环持续时间作为主要措施。 8。哈格里夫的测试评估皮肤痛觉过敏。 9。电冯·弗雷（Electro von Frey）毛发，以评估受伤后的机械 - 高敏度。 此外，核心将按照鞋底劳动力中的特定项目的需要，追求新型的电生理和行为评估工具的开发。