Brain Aging, AD and Dementia in Low and Middle Income Countries (LMICs) and Low Resource Settings: Gender, Genetics, Risk Factors, Pathophysiology and Prevention

低收入和中等收入国家 (LMIC) 和资源匮乏环境中的脑衰老、AD 和痴呆症：性别、遗传学、危险因素、病理生理学和预防

• 批准号: 9914747
• 负责人: Maria C Carrillo
• 金额: $ 4.99万
• 依托单位: UNIVERSITY OF TEXAS RIO GRANDE VALLEY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9914747
• 关键词: Academy; Achievement; Address; Africa; African; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Argentina; Australia; Bangladesh; Behavior Therapy; Behavioral Symptoms; Biological Markers; Brazil; Canada; Caregivers; Caring; China; Cities; Collaborations; Congo; Consensus; Country; Dementia; Discipline; Disease; Educational workshop; Epidemiological trend; Epidemiology; Etiology; Event; Family; Fostering; Foundations; France; Frequencies; Functional disorder; Funding; Future; Gender; Geographic Locations; Goals; Health; Health Status; Healthcare; High Prevalence; Incidence; Income; India; Individual; Institutes; International; Japan; Kenya; Knowledge; Knowledge acquisition; Leadership; Locales; Mental Health; Mentors; Meta-Analysis; Minority; Morocco; Netherlands; Neurology; New Zealand; Nigeria; Paper; Participant; Population; Population Heterogeneity; Prevalence; Prevention; Prevention strategy; Productivity; Public Health; Publishing; Publishing Peer Reviews; Recurrence; Reporting; Research; Research Design; Research Personnel; Research Training; Resources; Risk; Risk Factors; Schedule; Senegal; Series; Singapore; South Africa; Support System; Sweden; Texas; Time; Travel; Tunisia; Universities; Ursidae Family; Venezuela; Videoconferences; aging brain; base; career; caregiving; cerebrovascular; data sharing; disability; effective intervention; experience; follow-up; genetic risk factor; high risk; implementation science; improved; innovation; interest; international partnership; low and middle-income countries; meetings; multidisciplinary; outcome forecast; programs; protective factors; rural area; social; success; symposium

PROJECT SUMMARY People residing in low-resource settings suffer a higher burden of Alzheimer´s disease and related dementias (ADRD). This is due not only to higher prevalence of ADRD and lower support for its caregivers and families, but also due to a significant knowledge gap about ADRD in diverse US populations residing in low-resource settings and populations that reside in low and middle income countries (LMICs). The objective of the proposed project is to plan, organize and conduct an international scientific meeting, to foster and create a collaborative effort to share data and knowledge on risk, protective factors, and study designs taking advantage of the advances in the –OMICS and analyze the ADRD situation in low-resource settings and LMICs, and define important questions that will accelerate minority aging research in the US and abroad. The 3-day International Symposium on Brain Aging & Dementia in Low-Resource Settings and LMICs will be held in Nairobi, Kenya, a central geographic location that will facilitate attendance of researchers from the developing world, particularly Africa. It will build upon expertise and initiatives developed during its 4 prior editions and will similarly include expert speakers from diverse impacted and concerned nations, including Argentina, Australia, Brazil, Canada, China, DR Congo, France, India, Bangladesh, Japan, Kenya, Morocco, Nigeria, New Zealand, Netherlands, Senegal, Singapore, South Africa, Sweden, Tunisia, UK, US, Venezuela. For the conference, we will leverage resources of UTRGV Alzheimer´s Disease Resource Center for Minority Aging (AD-RCMAR), led by PI Gladys Maestre, and the global field leadership of Dr. Rajesh Kalaria, and Dr. María Carrillo from the US-based Alzheimer´s Association. The Specific Aims are to: 1. Prepare the scientific program of the International Symposium on Brain Aging & Dementia in Low-Resource Settings and LMICs. 2 Hold the conference in Nairobi, Kenya, a globally central hub city and hotel venue within reach and travel for invited speakers, other foreign delegates, and local participants, and readily accessible to others online. 3. In topic-focused, online-accessible interactive panels/sessions, identify how new research and healthcare projects or follow-up of existing/prior ones can be enhanced or expanded to improve research and implementation of actions identified as high-priority needs in diverse aging populations in low-resource settings to decrease the burden of ADRD. 4. Promote careers in minority aging research focused on ADRD in low- resource settings, by direct mentoring and active engagement of junior researchers and providing networking opportunities, and forge domestic and international partnerships to leverage complementary researchers’ and agencies’ interests and strengths. 5. Produce and disseminate a detailed meta-analysis and/or consensus report based on conference proceedings and participants' input on the status of factors influencing dementia prevalence/incidence and strategies for prevention and improving care and support, via a peer-reviewed published paper, a series of 4 videoconferences, and the 2021 Alzheimer´s Disease Facts & Figures Report.

项目概要 居住在资源匮乏地区的人们患阿尔茨海默病和相关痴呆症的负担更高 （ADRD）这不仅是因为 ADRD 患病率较高，而且对其照顾者和家庭的支持较少， 但也由于居住在资源匮乏地区的不同美国人群对 ADRD 的认识存在显着差距 居住在低收入和中等收入国家 (LMIC) 的环境和人口。 拟议的项目是规划、组织和举办一次国际科学会议，以培育和创建 协作努力共享有关风险、保护因素和研究设计的数据和知识 利用 –OMICS 的进步并分析资源匮乏环境中的 ADRD 情况， 中低收入国家，并确定将加速美国和国外少数族裔老龄化研究的重要问题。 为期 3 天的资源匮乏地区和中低收入国家脑老化和痴呆症国际研讨会将于 会议在肯尼亚内罗毕举行，该会议地理位置优越，有利于来自世界各地的研究人员参加 它将以前 4 届会议期间开发的专业知识和举措为基础。 版本，同样将包括来自不同受影响和相关国家的专家演讲，包括 阿根廷、澳大利亚、巴西、加拿大、中国、刚果民主共和国、法国、印度、孟加拉国、日本、肯尼亚、摩洛哥、 尼日利亚、新西兰、荷兰、塞内加尔、新加坡、南非、瑞典、突尼斯、英国、美国、委内瑞拉。 对于本次会议，我们将利用 UTRGV 少数民族阿尔茨海默病资源中心的资源 老龄化 (AD-RCMAR)，由 PI Gladys Maestre 领导，全球现场领导由 Rajesh Kalaria 博士和 Dr. Rajesh Kalaria 领导。 来自美国阿尔茨海默病协会的 María Carrillo 具体目标是： 1. 准备科学依据。 资源匮乏地区和中低收入国家脑老化和痴呆症国际研讨会计划 2。 在肯尼亚内罗毕举办会议，这是全球中心枢纽城市，酒店场地触手可及，出行方便 受邀演讲者、其他外国代表和当地参与者，其他人也可以轻松在线访问。 3. 在以主题为中心、可在线访问的交互式小组/会议中，确定​​新的研究和医疗保健如何 可以加强或扩大现有/先前项目或后续项目，以改进研究和 实施被确定为资源匮乏环境中不同老龄化人口高度优先需求的行动 减轻 ADRD 的负担 4. 促进以低收入人群 ADRD 为重点的少数族裔老龄化研究事业。 通过初级研究人员的直接指导和积极参与以及提供网络来设置资源 机会，并建立国内和国际伙伴关系，以利用互补的研究人员和 5. 制定并传播详细的荟萃分析和/或共识。 基于会议记录和参与者对影响痴呆症因素状况的意见的报告 通过同行评审，了解患病率/发病率以及预防和改善护理和支持的策略 发表的论文、一系列 4 场视频会议以及 2021 年阿尔茨海默病事实和数据报告。

项目成果

Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization.

拉丁美洲预防认知衰退生活方式干预倡议 (LatAm-FINGERS)：研究设计和协调。

• 发表时间: 2023-09
• 作者: Crivelli, Lucia;Calandri, Ismael Luis;Suemoto, Claudia Kimie;Salinas, Rosa María;Velilla, Lina Marcela;Yassuda, Mônica Sanches;Caramelli, Paulo;Lopera, Francisco;Nitrini, Ricardo;Sevlever, Gustavo Emilio;Sosa, Ana Luisa;Acosta, Daisy;Baietti
• 通讯作者: Baietti