VASCULITIS CLINICAL RESEARCH CONSORTIUM (VCRC) STUDY OF CHURG-STRAUSS SYNDROME

血管炎临床研究联盟 (VCRC) 对 CHURG-STRAUSS 综合征的研究

• 批准号: 7608199
• 负责人: Carol Langford
• 金额: $ 0.06万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608199
• 关键词: Asthma; Biological Markers; Blood; Chemicals; Churg-Strauss Syndrome; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Gene Proteins; Grant; Institution; Laboratory Research; Measures; Medical; Methods; Patients; Physicians; Purpose; Research; Research Personnel; Resources; Risk; Signs and Symptoms; Source; Specimen; Time; United States National Institutes of Health; Urine; Vasculitis; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is often difficult for both patients and physicians to determine how ¿active¿ a person¿s Churg-Strauss syndrome (CSS) is at any given time, yet it is critically important to determine disease activity in order to properly treat this disease. In CSS, this is further complicated by difficulties differentiating the activity of the underlying asthma from activity of the vasculitis component of the disease. Clinical signs and symptoms of disease are quite helpful but may be due to more than one medical problem. The purpose of this study is to use new scientific methods to discover new biological markers of disease activity in patiens with CSS that will serve one or more of the following uses: measure the amount of active disease occurring at any given time; predict what types of problems patients are at risk for in order to help choose the best therapy; and predict whether patients will respond to specific treatments. To help discover these new markers, we will follow a large group of patients with CSS at VCRC Vasculitis Centers over several years. Clinical information and blood and urine specimens will be collected on a regular basis. These specimens will be sent to research laboratories that are looking to discover new proteins, genes, and other chemicals that could serve as new ¿biomarkers¿.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 患者和医生通常都难以确定一个人如何在任何给定时间进行活动，但确定疾病活动以正确治疗这种疾病至关重要。在CSS中，难以将基本哮喘的活性与疾病的血管炎的活性区分开来更加复杂。疾病的临床体征和症状非常有帮助，但可能是由于多个医疗问题所致。 这项研究的目的是使用新的科学方法来发现具有CSS模式的新生物学标志物，这些模式将用于以下一种或多种用途：测量在任何给定时间发生的活性疾病量；预测患者有哪些类型的问题，以帮助选择最佳疗法；并预测患者是否会对特定的治疗做出反应。 为了帮助发现这些新标记，我们将在几年内关注VCRC血管炎中心的大量CSS患者。临床信息以及血液和尿液标本将定期收集。这些标本将发送给希望发现新蛋白质，基因和其他化学物质的研究实验室，这些化学物质可以用作新的生物标志物。