2020 New Antibacterial Discovery and Development GRC/GRS

2020 新抗菌药物发现与开发 GRC/GRS

基本信息

批准号：
9913855
负责人：
Ruben Tommasi
金额：
$ 0.65万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-05 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9913855
关键词：
Academia Address Adjuvant Anti-Bacterial Agents Antibiotic Resistance Antibiotics Area Bacterial Infections Basic Science Biological Biotechnology Cells Charge Chemicals Clinic Clinical Clinical Pathways Clinical Trials Design Collaborations Communities Community Networks Companions Critical Thinking Data Development Diagnosis Drug Industry Drug resistance ESKAPE pathogens Environment Failure Fostering Foundations Future Generations Government Government Agencies Gram-Negative Bacteria Human Immune Industry Infection Leadership Learning Medical Medicine Membrane Modeling National Institute of Allergy and Infectious Disease Organism Organizational Change Outcome Participant Patients Pharmaceutical Preparations Program Development Research Research Personnel Risk-Taking Scientist Talents Therapeutic Time Translational Research Validation antimicrobial drug career clinical candidate clinical development drug development drug discovery drug resistant bacteria experience innovation interdisciplinary approach interest lead optimization meetings next generation novel novel strategies programs research facility success support network symposium

项目摘要

Summary The 2020 Gordon Research Conference on New Antibacterial Discovery and Development and the companion Gordon Research Seminar will bring highly experienced leaders in antibacterial drug discovery and development together with young investigators and those new to the field of antibiotics research in order to enable the next generation of safe and effective drugs. Discussion leaders and speakers are chosen from academia, industry, and government agencies to emphasize the breadth of talent and leadership necessary to drive innovation around target discovery and validation, hit identification and chemical optimization, and clinical trial design and execution. Previous meetings have defined the problem of antibiotic resistance, the challenges in antibiotic discovery and development faced over the past two decades, and the need for new pathways for clinical development. Those meetings have successfully created a community of idea generation and collaboration in what is otherwise a highly competitive scientific arena. This meeting will build on those foundations by exploring 1) Communicate novel approaches towards target selection and identification of cell active compounds, 2) Communicate key learnings from recent clinical development programs, and 3) Communicate and discuss novel, non-traditional approaches to antibacterial discovery and development in the next decade. Many strategic and organizational changes have taken place in the biotech and pharmaceutical industry over the last few years as well as a shift in emphasis at academic and government research facilities from early basic science to translational research. Because of the ever-changing environment, there has never been a more critical time for fostering a community of intellectuals dedicated to innovation and calculated risk-taking. This GRC/GRS will enable critical thinking, robust discussions around data gathering and interpretation, and learning from each other's challenges and successes. Most importantly the GRC/GRS meeting will provide a community and support network for scientists who have dedicated their careers to one of the most difficult and essential areas of human medicine.

概括 2020 年戈登新抗菌药物发现和开发研究会议以及同期举办的戈登研究研讨会将带来抗菌药物发现领域经验丰富的领导者与年轻研究人员和抗生素研究领域的新人一起开发，以便使下一代安全有效的药物成为可能。讨论领袖和演讲者选自学术界、工业界和政府机构强调人才的广度和领导力所必需的围绕目标发现和验证、命中识别和化学优化推动创新，以及临床试验设计和执行。之前的会议已经明确了抗生素耐药性问题，过去二十年抗生素发现和开发面临的挑战以及对新抗生素的需求临床开发途径。这些会议成功地创建了一个创意产生社区以及在竞争激烈的科学领域进行合作。这次会议将在这些基础上通过探索 1) 交流细胞目标选择和识别的新方法活性化合物，2) 交流近期临床开发项目的重要经验教训，以及 3) 交流和讨论抗菌药物发现和开发的新颖、非传统方法下一个十年。多年来，生物技术和制药行业发生了许多战略和组织变革过去几年以及学术和政府研究机构的重点从早期的转变基础科学到转化研究。由于环境不断变化，从来没有现在是培养致力于创新和有计划地承担风险的知识分子群体的关键时刻。该 GRC/GRS 将促进批判性思维、围绕数据收集和解释的激烈讨论，以及从彼此的挑战和成功中学习。最重要的是，GRC/GRS 会议将提供为那些将自己的职业生涯奉献给最困难和最困难的领域之一的科学家提供的社区和支持网络人类医学的重要领域。