INFLAMMATORY RESPONSE TO DIETS BETWEEN ASIANS AND CAUCASIANS

亚洲人和白人对饮食的炎症反应

基本信息

批准号：
7606949
负责人：
GEORGE L KING
金额：
$ 0.47万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2008-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7606949
关键词：
American Asian Americans Asians Biochemical Caucasians Caucasoid Race Computer Retrieval of Information on Scientific Projects Database Development Diabetes Mellitus Diet Far East Funding Gingival Crevicular Fluid Grant Heart Diseases Inflammatory Inflammatory Response Institution Measures Plasma Protein Kinase C Research Research Personnel Resources Risk Source United States National Institutes of Health caucasian American monocyte

American Asian Americans Asians Biochemical Caucasians Caucasoid Race Computer Retrieval of Information on Scientific Projects Database Development Diabetes Mellitus Diet Far East Funding Gingival Crevicular Fluid Grant Heart Diseases Inflammatory Inflammatory Response Institution Measures Plasma Protein Kinase C Research Research Personnel Resources Risk Source United States National Institutes of Health caucasian American monocyte

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项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is that Asian Americans compared to Caucasians, will be at higher risk of developing a pro-inflammatory state that may contribute to the development of heart disease and diabetes when they change from a traditional Asian diet to a typical American diet. These inflammatory responses will be reflected by the activation of monocytes as measured by protein kinase C (PKC), a known activator of monocytes. It is hypothesized that these inflammatory responses in the gingival crevicular fluid (GCF) will reflect similar changes of these markers in the plasma and monocytes. The specific aims of this study are to compare the inflammatory responses (primary PKC activation in monocytes), between Far-East Asian Americans and Caucasian Americans, when they change from a traditional Asian diet to a typical American diet and also to correlate the biochemical changes of inflammatory responses in the plasma and monocytes with those in the gingival crevicular fluid.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。这项研究的假设是，与高加索人相比，亚裔美国人将面临促炎性状态的风险更高，当他们从传统的亚洲饮食变为典型的美国饮食时，可能会导致心脏病和糖尿病的发展。这些炎症反应将通过单核细胞的激活来反映，如蛋白激酶C（PKC）测量，蛋白激酶C（PKC）是已知的单核细胞活化剂。假设在牙龈裂缝液（GCF）中的这些炎症反应将反映出血浆和单核细胞中这些标记的类似变化。这项研究的具体目的是比较遥远的美国人和高加索的美国人之间的炎症反应（单核细胞中的主要PKC激活），当他们从传统的亚洲饮食变为典型的美国饮食，并将血浆和单核细胞炎症中炎症反应的生物化学变化与这些杂种的生化反应相关联。