STUDY OF IMMUNE EFFECTS ON SLEEP AND (HIV) TREATMENT ON APNEA (SIESTA)

免疫对睡眠的影响和（HIV）治疗对呼吸暂停（午睡）的研究

• 批准号: 7607488
• 负责人: PHILIP L SMITH
• 金额: $ 7.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607488
• 关键词: Address; Apnea; Cellular Immunity; Computer Retrieval of Information on Scientific Projects Database; Disruption; Drowsiness; Fatigue; Functional disorder; Funding; Grant; HIV; HIV Infections; Highly Active Antiretroviral Therapy; Immune; Institution; Lead; Life; Metabolic; Quality of life; Research; Research Personnel; Resources; Severities; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Source; United States National Institutes of Health; airway obstruction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is know that HIV itself is associated with disruptions in sleep with resultant daytime fatigue, somnolence, and impaired quality of life. HAART therapy is extending life but leading to metabolic derangements that predispose to sleep apnea. The major hypothesis of this study is that HIV infection, HAART, and associated alterations in humoral factors and cellular immunity lead to sleep disruption and sleep apnea which both cause daytime dysfunction. To address this hypothesis, two specific aims are proposed. 1) Elucidate the effects of HIV and HAART on nocturnal sleep architecture and daytime function. 2) Delineate the effects of HIV and HAART on the severity of upper airway obstruction and sleep.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 众所周知，艾滋病毒本身与睡眠中断有关，导致白天疲劳，脾气暴躁和生活质量受损。 HAART治疗正在延长寿命，但导致代谢危险易于睡眠呼吸暂停。这项研究的主要假设是，艾滋病毒感染，HAART和相关的体液因素和细胞免疫的改变会导致睡眠破坏和睡眠呼吸暂停，这两者都会导致白天功能障碍。 为了解决这一假设，提出了两个具体目标。 1）阐明HIV和HAART对夜间睡眠结构和白天功能的影响。 2）描述HIV和HAART对上气道阻塞和睡眠严重程度的影响。