THE EFFECT OF STATIN USE ON VASCULAR FUNCTION IN HYPERTENSIVE SUBJECTS

他汀类药物的使用对高血压患者血管功能的影响

• 批准号: 7607464
• 负责人: PAMELA OUYANG
• 金额: $ 0.05万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607464
• 关键词: Atherosclerosis; Blood; Blood Vessels; Cardiovascular system; Cholesterol; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Functional disorder; Funding; Grant; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Individual; Inflammation; Institution; Lipids; Metabolism; Morbidity - disease rate; Nitric Oxide; Patients; Purpose; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health; arterial stiffness; cardiovascular risk factor; mortality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypertension, a common risk factor for atherosclerosis, occurs without a known or reversible cause in over 90% of cases, and adjunct strategies are needed to reduce its complications, such as vascular dysfunction. Clinical trials have shown that HMG-CoA reductase inhibitor (statin) therapy reduces cardiovascular mortality and morbidity. This benefit is seen in patients with and without high blood cholesterol levels. Non-lipid actions of statins including effects on the blood vessel wall, the microvasculature and systemic inflammation are likely to be responsible for this benefit. The purpose of this study is to more fully investigate the effects of statins on endothelial dysfunction (both conduit and microvascular), arterial stiffness, inflammation and impaired nitric oxide metabolism, which are potential pathophysiologic mechanisms leading to increased cardiovascular risk in hypertensive individuals.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 高血压是动脉粥样硬化的常见危险因素，在90％以上的病例中没有已知或可逆原因，需要辅助策略来减少其并发症，例如血管功能障碍。 临床试验表明，HMG-COA还原酶抑制剂（Statin）疗法降低了心血管死亡率和发病率。 在患有和没有高血液胆固醇水平的患者中可以看到这种好处。 他汀类药物的非脂动作用，包括对血管壁的影响，微脉管系统和全身性炎症的影响，可能会对这一益处负责。 这项研究的目的是更全面地研究他汀类药物对内皮功能障碍（导管和微血管疾病），动脉僵硬，炎症和一氧化氮代谢的影响，这些氧化物代谢是潜在的病理生理机制，这些机制导致高血压个体的心血管风险增加。