SOY ISOFLAVONE METABOLITE EQUOL

大豆异黄酮代谢物雌马酚

• 批准号: 7607790
• 负责人: KENNETH DAVID SETCHELL
• 金额: $ 6.74万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607790
• 关键词: Adult; Age-Months; Antibiotics; Bacteria; Blood; Bottle feeding; Breast Feeding; Cardiovascular system; Cattle; Clinical effectiveness; Computer Retrieval of Information on Scientific Projects Database; Diet; Drug Kinetics; Eating; Fiber; Funding; Future; Grant; Health; Infant; Institution; Intestines; Life; Menopause; Milk; Osteoporosis prevention; Predisposition; Production; Questionnaires; Recording of previous events; Research; Research Personnel; Resources; Role; Source; Soy Foods; United States National Institutes of Health; Urine; Weaning; clinically relevant; equol; response; soy; soy protein isolate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Equol is an important metabolite made in the body when soy is eaten. It is made by intestinal bacteria and not found in the urine and blood of infants before 4-months of age. We will determine when equol first appears in early life and whether it is breast feeding, cows milk formula or soy formula, or the composition of the post-weaning diet that predispose to the production of equol. Breast-feeding leads to differences in intestinal bacterial colonization and a lower pH compared with bottle-feeding, and this is expected to facilitate equol formation. In adults we will examine three broad dietary groups those consuming low, medium and high fiber as determined by a validated diet history questionnaire, to determine the role of adult diet in predisposition to make equol. We will also determine the pharmacokinetics of equol formation, and the long-term stability of equol-production in adults and its response to antibiotic use. For unknown reasons only one-third of adults consuming soy foods make equol. Recent studies of osteoporosis prevention, cardiovascular health, and menopause have shown that beneficial effects from soy foods are significantly greater in people who are 'equol-producers' compared with those unable to make equol. Since there are advantages to being an equol-producer it is important to understand the factors governing equol production. Given the clinical relevance of equol a greater understanding of factors governing its production is essential. This will facilitate future strategies to manipulate equol production and enhance the overall clinical effectiveness of soy foods.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 雌马酚是食用大豆时体内产生的一种重要代谢物。 它由肠道细菌产生，4 个月前婴儿的尿液和血液中不存在。我们将确定雌马酚在生命早期何时首次出现，以及是否是母乳喂养、配方奶粉或大豆配方奶粉，或者断奶后饮食的成分容易产生雌马酚。与奶瓶喂养相比，母乳喂养会导致肠道细菌定植差异和较低的 pH 值，这有望促进雌马酚的形成。 在成人中，我们将检查通过经过验证的饮食史调查问卷确定的低、中和高纤维消耗的三大饮食群体，以确定成人饮食在产生雌马酚的倾向中的作用。 我们还将确定雌马酚形成的药代动力学，以及成人中雌马酚产生的长期稳定性及其对抗生素使用的反应。 由于未知的原因，只有三分之一食用大豆食品的成年人会产生雌马酚。最近有关骨质疏松症预防、心血管健康和更年期的研究表明，与无法产生雌马酚的人相比，大豆食品对“产生雌马酚”的人的有益效果明显更大。 由于成为雌马酚生产者有很多优势，因此了解控制雌马酚生产的因素非常重要。 鉴于雌马酚的临床相关性，更好地了解控制其产生的因素至关重要。这将有助于未来控制雌马酚生产的策略并提高大豆食品的整体临床效果。