IMMUNOLOGIC MEMORY FOLLOWING PNEUMOCOCCAL, HEP B, AND MEASLES VACCINATION P1061

肺炎球菌、乙型肝炎和麻疹疫苗接种后的免疫记忆 P1061

• 批准号: 7607895
• 负责人: Sharon A Nachman
• 金额: $ 0.4万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-23 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607895
• 关键词: Blood Tests; Cells; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Diphtheria-Tetanus-Pertussis Vaccine; Dose; Evaluation; Funding; Grant; Hepatitis B; Hepatitis B Vaccines; Hepatitis B Virus; Highly Active Antiretroviral Therapy; Immunization; Immunologic Memory; Immunologics; Infection; Institution; Measles; Measles-Mumps-Rubella Vaccine; Pertussis; Pneumococcal Infections; Pneumococcal conjugate vaccine; Polysaccharides; Polyvalent pneumococcal vaccine; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Vaccination; Vaccines; fighting; immunogenicity; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This subject is eligible to participate in this substudy because they have participated in P1024, "Evaluation of the Immunogenicity of Pneumococcal Conjugate Vaccine and Routine Pediatric Immunizations in HIV-Infected Children Treated with Highly Active Antiretroviral Therapy (HAART)." P1024 was a study to see how well the following vaccines can help children fight different types of infection: Pneumococcal Conjugate Vaccine (PCV), Pneumococcal Polysaccharide Vaccine (PPV), Measles-Mumps-Rubella Vaccine (M-M-R¿II), Diphtheria-Tetanus-Pertussis Vaccine (DTaP) and Hepatitis B Vaccine (HBV). This substudy will look at whether or not the subject has developed "immunologic memory" from the vaccines received in P1024 . To see if they have developed protective cells that remember how to fight pneumococcal, measles, and hepatitis B infection). This substudy will check if they are still protected from the following: pneumococcal infection, measles, and/or hepatitis B virus. This substudy will not look at immunologic protection against pertussis. This substudy will look at whether the subject has developed protective cells that remember how to fight pneumococcal, measles, and hepatitis B infection by giving you/your child additional (booster) doses of Pneumococcal Conjugate Vaccine (PCV) or Pneumococcal Polysaccharide Vaccine (PPV); Measles-Mumps-Rubella Vaccine (M-M-R¿II); and Hepatitis B Vaccine (HBV) and looking at blood tests that test for responses to these vaccines. The child will not receive a booster dose of Diphtheria-Tetanus-Pertussis Vaccine (DTaP) as part of this substudy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 中心，不一定是研究者的机构。 该受试者有资格参加本次研究，因为他们参加了 P1024，“对接受高效抗逆转录病毒疗法 (HAART) 治疗的 HIV 感染儿童的肺炎球菌结合疫苗和常规儿科免疫的免疫原性评估是 P1024 的一项研究。”了解以下疫苗如何帮助儿童对抗不同类型的感染： 肺炎球菌结合疫苗疫苗（PCV）、肺炎球菌多糖疫苗（PPV）、麻疹-腮腺炎-风疹疫苗（M-M-R¿II）、白喉-破伤风-百日咳疫苗（DTaP）和乙型肝炎疫苗（HBV）。 这项子研究将考察受试者是否从 P1024 中接种的疫苗中形成了“免疫记忆”，以了解他们是否已经形成了记住如何对抗肺炎球菌、麻疹和乙型肝炎感染的保护性细胞。如果他们仍然受到以下保护：肺炎球菌感染、麻疹和/或乙型肝炎病毒，则本次研究将不考虑针对肺炎球菌感染、麻疹和/或乙型肝炎病毒的免疫保护。百日咳。 这项子研究将通过给您/您的孩子额外（加强）剂量的肺炎球菌结合疫苗 (PCV) 或肺炎球菌多糖疫苗 (PPV) 来观察受试者是否已发育出能够记住如何对抗肺炎球菌、麻疹和乙型肝炎感染的保护性细胞。 ; 麻疹-腮腺炎-风疹疫苗（M-M-R¿II）；和乙型肝炎作为本次研究的一部分，儿童将不会接受加强剂量的白喉-破伤风-百日咳疫苗 (DTaP)。