CHARACTERIZATION OF DAPTOMYCIN PHARMACOKINETICS AND GLOMERULAR FILTRATION RATE

达托霉素药代动力学和肾小球滤过率的表征

• 批准号: 7606893
• 负责人: Vinay Manjunath Pai
• 金额: $ 1.96万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606893
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Daptomycin; Dose; Drug Kinetics; Equation; Funding; Glomerular Filtration Rate; Grant; Institution; Obesity; Plasma; Population; Protein Binding; Purpose; Renal clearance function; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health; Weight; base; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is - 1) To compare the single-dose plasma concentration versus time profile for daptomycin in morbidly obese subjects compared to matched healthy normal weight volunteers. 2) To compare differences in daptomycin renal clearance and protein binding in these two populations. 3) To derive an equation that better predicts daptomycin clearance in morbidly obese and normal weight subjects based on GFR and CLcr estimates.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是 - 1）与匹配的健康正常体重志愿者相比，在病态肥胖受试者中，单剂量血浆浓度与达托霉素的时间概况。 2）比较这两个人群中达霉素肾清除率和蛋白质结合的差异。 3）根据GFR和CLCR估计值，可以更好地预测病态肥胖和正常体重受试者的Daptomycin清除率的方程式。