ASTHMA AND BREATHLESSNESS IN SCHOOL AGE CHILDREN

学龄儿童的哮喘和呼吸困难

• 批准号: 7606710
• 负责人: THOMAS A. PLATTS-MILLS
• 金额: $ 1.6万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606710
• 关键词: Advertisements; Age; Allergic; Asthma; Child; Clinic; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Diagnostic; Dyspnea; Enrollment; Funding; Grant; Hospitals; Inflammatory; Institution; Mediator of activation protein; Non obese; Obesity; Pilot Projects; Research; Research Personnel; Resources; School-Age Population; Source; Students; United States National Institutes of Health; high school; tool; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A pilot study enrolling 50 High School students age 12-19 (30 MD diagnosed, obese asthmatics, referred to our clinic for suspected asthma or by advertisement and 20 non-asthmatic controls) will be conducted in a hospital setting to investigate the relationship between breathlessness, obesity, and asthma. Our hypothesis is that a significant portion of obese children complaining of breathlessness will be due to deconditioning rather than asthma. Accordingly the profile of the inflammatory mediators will reflect such a trend by showing increased amounts of Th2, allergic inflammatory mediators in asthmatics while increased amounts of Th1 inflammatory mediators in obese, non-asthmatics. It is possible that these inflammatory marker profiles could be used as a diagnostic tool to help distinguish subjects with asthma from those who are only deconditioned.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 一项招募12-19岁高中学生的试点研究（诊断为30名MD，肥胖的哮喘患者，向我们的诊所提到可疑的哮喘或通过广告和20种非侵入性控制），将在医院环境中进行研究，以调查呼吸困难，肥胖，肥胖和哮喘之间的关系。 我们的假设是，大部分肥胖儿童抱怨呼吸困难是由于解剖而不是哮喘所致。 因此，炎症介质的特征将通过显示哮喘患者中TH2，过敏性炎症介质的量增加，而在肥胖，非asthmatmatics中的Th1炎症介质量增加。 这些炎症标记物概况可能可以用作诊断工具，以帮助将哮喘与仅被解结的受试者区分开。