CROSS-SECTIONAL AND LONGITUDINAL STUDY OF ENDOTHELIAL FUNCTION BY BRACHIAL FLOW-

通过肱动脉血流对内皮功能进行横断面和纵向研究

• 批准号: 7606466
• 负责人: MICHAEL P DUBE
• 金额: $ 15.06万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606466
• 关键词: Anti-Retroviral Agents; Blood; Blood Vessels; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Cross-Sectional Studies; Development; Disease; Enrollment; Evaluation; Functional disorder; Funding; Grant; HIV-1; Infection; Institution; Insulin Resistance; Longitudinal Studies; Nature; Pharmaceutical Preparations; Reporting; Research; Research Personnel; Resources; Risk; Source; Specific qualifier value; Staging; United States National Institutes of Health; heart disease risk

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Highly active antiretroviral treatment (HAART) results in impressive improvement in human immunodeficiency virus-1 (HIV)-related disease. However, drug treatment may increase the risk of heart disease. Developing high blood cholesterol and abnormal blood vessel function may cause this risk. By studying a variety of subjects with HIV infection, both on HAART and not, we propose to establish the variables that are most important at causing abnormal blood vessel function at various stages of treatment. The primary objective is to assess whether the endothelial dysfunction that has been reported during prolonged treatment is primarily the result of the high blood cholesterol and insulin resistance that is associated with the development of lipodystophy. The study will be observational in nature and will not specify what HIV treatment subjects will receive. Cross-sectional and longitudinal components are included. Drug-naive subjects who are enrolled into the cross-sectional study may also be eligible for the longitudinal evaluations. The longitudinal study will primarily be exploratory in nature.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 高度活跃的抗逆转录病毒治疗（HAART）导致人类免疫缺陷病毒1（HIV）相关疾病的令人印象深刻的改善。但是，药物治疗可能会增加患心脏病的风险。发展高血液胆固醇和异常血管功能可能会导致这种风险。通过研究各种HIV感染的受试者，无论是在HAART上还是没有HAART，我们都提出建立最重要的变量，这些变量在各个治疗阶段都在引起血管异常。 主要目的是评估长期治疗期间报道的内皮功能障碍是否主要是与脂型发展有关的高血液胆固醇和胰岛素抵抗的结果。这项研究本质上是观察性的，不会指定将收到哪些艾滋病毒治疗对象。包括横截面和纵向成分。参与横断面研究的药物受试者也可能有资格进行纵向评估。纵向研究主要是探索性的。