THE GENETICS OF CHOLESTEROL ABSORPTION

胆固醇吸收的遗传学

• 批准号: 7606342
• 负责人: Helen Haskell Hobbs
• 金额: $ 0.13万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606342
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Dietary Cholesterol; Enterocytes; Funding; Genes; Genetic; Goals; Grant; Individual; Institution; LDL Cholesterol Lipoproteins; Mediating; Membrane Proteins; Plasma; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Variant; absorption; cardiovascular risk factor; cholesterol absorption

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Plasma levels of LDL-cholesterol, a key cardiovascular risk factor, are directly related to the fractional absorption of dietary cholesterol. Genetic differences between individuals contribute significantly to differences in cholesterol absorption. Recently a gene NPC1L1, encoding a membrane protein has been implicated in mediating transport of dietary cholesterol from the gut lumen into enterocytes. The goal of this project is to determine if sequence variations in NPC1L1 contribute to differences in fractional absorption of cholesterol.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 LDL-胆固醇的血浆水平是关键的心血管危险因素，与饮食中胆固醇的分数直接相关。 个体之间的遗传差异对胆固醇吸收的差异显着贡献。 最近，编码膜蛋白的基因NPC1L1与将饮食中胆固醇从肠道内流腔介导到肠细胞中的转运有关。 该项目的目的是确定NPC1L1中的序列变化是否有助于胆固醇分数吸收的差异。