EFFECT OF EXERCISE TRAINING/NUTRITIONAL SUPPORT DURING PROLONGED BED REST

长期卧床期间运动训练/营养支持的效果

• 批准号: 7606351
• 负责人: BENJAMIN D LEVINE
• 金额: $ 4.49万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606351
• 关键词: Astronauts; Atrophic; Bed rest; Bone Resorption; Cardiac; Cardiovascular Deconditioning; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Depth; Development; Disuse Atrophy; Exercise; Exposure to; Fracture; Funding; Grant; Hypovolemia; Individual; Injury; Institution; International; Kidney Calculi; Lead; Microgravity; Mission; Morbidity - disease rate; Muscle; Muscular Atrophy; Musculoskeletal System; Myocardium; Nutritional Support; Orthostatic Hypotension; Planet Mars; Recovery; Reflex action; Research; Research Personnel; Resources; Risk; Skeletal Muscle; Source; Space Flight; Syncope; System; Testing; Time; Training; United States National Institutes of Health; Work; body system; bone; bone strength; demineralization; practical application; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sustained exposure to microgravity leads to adaptive changes in the cardiovascular and musculoskeletal systems that may impair normal function and result in substantial morbidity. For example cardiovascular deconditioning caused by cardiac atrophy, hypovolemia, or limited reflex responsiveness may lead to orthostatic hypotension and syncope. Disuse atrophy of skeleltal muscle will diminish work capacity and may lead to muscle injury. Bone demineralization increases the risk of kidney stone formation, and may reduce bone strength increasing the risk of fracture. Bone resorption may be particularly severe after long duration space flight with uncertain recovery. Virtually all the changes previously observed in short duration space missions may be exacerbated during long duration missions, such as those required aboard the International Space Station, or a mission to Mars. However despite in depth study, the optimal countermeasure for each system has not yet been defined. More importantly, previous work has focused primarily on one organ system at a time, ignoring the interaction among systems, and preventing the development and practical application of a specific countermeasure for an individual astronaut that might be effective for the heart, muscles and bones. The global objective of this proposal is to test an integrated countermeasure that will be effective against cardiovcascular deconditioning, skeletal muscle atrophy, and bone demineralizqtion, and that ultimately can be applied practically aboard the International Space Station or a mission to Mars.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 持续暴露于微重力的导致心血管和肌肉骨骼系统的适应性变化，这些系统可能会损害正常功能并导致大量发病率。 例如，心血管萎缩，血容量低或反射反应性有限可能导致体位性低血压和晕厥。 skeleltal肌肉的萎缩会降低工作能力，并可能导致肌肉损伤。 骨脱矿化会增加肾结石形成的风险，并可能降低骨骼强度增加骨折的风险。持续时间长时间飞行后，骨吸收可能特别严重，并且恢复不确定。 实际上，在短期空间任务中以前观察到的所有更改可能会在漫长的持续时间任务中加剧，例如需要在国际空间站上的那些任务，或者是火星的任务。 然而，尽管进行了深入研究，但尚未定义每个系统的最佳对策。 更重要的是，以前的工作一次主要集中在一个器官系统上，忽略了系统之间的相互作用，并防止对单个宇航员的特定对策的开发和实际应用，这可能对心脏，肌肉和骨骼有效。 该提案的全球目标是测试综合的对策，该综合措施将有效地防止心脏疾病，骨骼肌肉萎缩和骨骼脱氨基化，最终可以实际上应用国际空间站或火星的任务。