Screening Chest CT to Detect Interstitial Lung Disease in Systemic Sclerosis

筛查胸部 CT 以检测系统性硬化症中的间质性肺疾病

基本信息

批准号：
9906173
负责人：
Elana Bernstein
金额：
$ 17.31万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9906173
关键词：
Adult Affect Area Arthritis Autoimmune Process Biological Biological Markers Carbon Monoxide Cause of Death Chest Clinical Clinical Investigator Clinical Practice Guideline Clinical Trials Consensus Crackles Cross-Sectional Studies Cyclophosphamide Data Detection Development Plans Diffusion Disease Dyspnea Early Intervention Enrollment Environment Epidemiologic Methods Epidemiology Exertion Extracellular Matrix Foundations Funding Goals Gold High Resolution Computed Tomography Hospitalization Inflammation Interleukin-6 Interstitial Lung Diseases Intervention Intervention Studies Investigation Knowledge Laboratories Lead Life Longitudinal Studies Master&apos s Degree Matrilysin Medicine Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Multicenter Studies Natural History Nature Newly Diagnosed Oxygen Patients Performance Pharmaceutical Preparations Phenotype Population Positioning Attribute Prevalence Prevention Preventive Intervention Primary Prevention Prospective cohort study Public Health Schools Publications Pulmonary Surfactant-Associated Protein D Pulmonary function tests Research Research Personnel Resources Respiratory physiology Rest Rheumatism Rheumatology Scanning Secondary Prevention Statistical Models Surveys Symptoms Systemic Scleroderma Testing Time Training Universities Variant Venous blood sampling Vital capacity Walking Work alveolar epithelium base career career development cell injury chest computed tomography clinical investigation clinical practice clinically relevant disease diagnosis epidemiology study experience improved improved outcome lung imaging meetings mycophenolate mofetil prevent professor research and development rheumatologist screening screening guidelines skills symposium tertiary prevention

项目摘要

Project Summary/Abstract Candidate: Dr. Bernstein is Assistant Professor of Medicine in the Division of Rheumatology at Columbia University. She is a clinical investigator with 12 total and 7 first-author original research publications, previous funding from the Arthritis Foundation and a KL2, and current funding from the Rheumatology Research Foundation. She has a Master’s Degree in Clinical and Translational Investigation. Her long-term career goal is to become an independent investigator in rheumatology who leads both clinical and epidemiological investigations of early interstitial lung disease (ILD) in systemic sclerosis (SSc), and who develops and tests interventions for the prevention of ILD in SSc. Career Development Plan: Dr. Bernstein and her mentors have crafted a career development plan intended to lead to independence by the end of the K23 award period, including training in advanced epidemiological methods and statistical modeling, qualitative and quantitative lung imaging, and clinical trials and multicenter studies. These new skills and knowledge will allow Dr. Bernstein to pursue a career as an independent clinical and epidemiologic investigator focused on prevention of ILD in SSc, and to submit a competitive R01 application during the fourth year of the K23. Environment: Dr. Bernstein has the protected time, facilities, resources, and expert support of the Department of Medicine to accomplish the mentored research and career development activities outlined in the K23. The Department of Medicine and Division of Rheumatology have guaranteed at least 75% protected time to devote to research and career development. She has regular opportunities for intellectual interactions with other investigators, including the opportunity to attend and present at a large number of recurring conferences and seminars relevant to her area of research. She will also engage in relevant coursework at the Columbia University Mailman School of Public Health. Research: Under the guidance of her expert mentorship team, led by Drs. David Lederer and Joan Bathon, Dr. Bernstein will perform a two-center prospective cohort study of 220 newly referred adults with SSc to achieve her Aims. The central hypothesis of this study is that screen-detected ILD in SSc is both biologically and clinically relevant, despite the absence of symptoms, because it (1) is associated with biomarkers of ILD and (2) precedes the onset of clinical symptoms and functional limitation and may therefore represent a “window of opportunity” for intervention. In Aim 1, Dr. Bernstein will conduct a cross-sectional study to establish the prevalence, clinical features, and biomarker profile of screen-detected ILD in SSc. In Aim 2, she will perform a longitudinal study to examine the progression of screen-detected ILD in SSc. Performing this K23 mentored research and obtaining training in advanced epidemiological methods and statistical modeling, qualitative and quantitative lung imaging, and clinical trials and multicenter studies will position her to become a successful independent investigator.

项目概要/摘要候选人：伯恩斯坦博士是哥伦比亚大学风湿病科医学助理教授她是一名临床研究者，发表过 12 篇原创研究论文，其中有 7 篇为第一作者。来自关节炎基金会和 KL2 的资助，以及风湿病研究的当前资助她拥有临床和转化研究硕士学位。她的长期职业目标是。成为风湿病学领域的独立研究者，领导临床和流行病学系统性硬化症 (SSc) 中早期间质性肺疾病 (ILD) 的研究，以及由谁开发和测试 SSc 职业发展计划中预防 ILD 的干预措施：Bernstein 博士和她的导师已经制定了职业发展计划，旨在在 K23 奖励期结束时实现独立，包括先进流行病学方法和统计模型、定性和定量肺的培训这些新技能和知识将使伯恩斯坦博士能够从事独立临床和流行病学调查员的职业生涯，专注于 SSc 中 ILD 的预防，并在 K23 环境的第四年提交竞争性 R01 申请：Bernstein 博士已完成。医学部受保护的时间、设施、资源和专家支持，以完成指导 K23 医学系概述的研究和职业发展活动。风湿病科保证至少75%的受保护时间投入研究和事业她有定期与其他研究人员（包括研究人员）进行智力互动的机会。有机会参加并出席与她的领域相关的大量定期会议和研讨会她还将在哥伦比亚大学梅尔曼公立学院从事相关课程。健康研究：在 David Lederer 博士和 Joan 博士领导的专家指导团队的指导下。 Bathon 和 Bernstein 博士将对 220 名新转诊的 SSc 成年人进行一项两中心前瞻性队列研究实现她的目标这项研究的中心假设是 SSc 中筛查检测到的 ILD 是生物学上的。尽管没有症状，但具有临床相关性，因为它 (1) 与 ILD 的生物标志物相关 (2) 在临床症状和功能限制出现之前，因此可能代表“窗口期”。在目标 1 中，伯恩斯坦博士将进行一项横断面研究来确定干预的“机会”。在目标 2 中，她将进行 SSc 中筛查检测的 ILD 的患病率、临床特征和生物标志物概况。纵向研究检查 SSc 中屏幕检测到的 ILD 的进展情况。研究并获得先进流行病学方法和统计模型、定性和定量肺部成像、临床试验和多中心研究将使她成为一名成功的独立调查员。