CHOLESTEROL EFFLUX FROM MACROPHAGES

巨噬细胞中的胆固醇流出

• 批准号: 7605009
• 负责人: SHOBHA GHOSH
• 金额: $ 0.84万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-20 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605009
• 关键词: Arterial Fatty Streak; Atherosclerosis; Attenuated; Blood Vessels; Cholesterol; Cholesterol Esters; Computer Retrieval of Information on Scientific Projects Database; Foam Cells; Funding; Grant; High Density Lipoproteins; Hydrolysis; Institution; Patients; Pilot Projects; Research; Research Personnel; Research Proposals; Resources; Risk; Serum; Source; United States National Institutes of Health; macrophage; monocyte; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of the study: Attenuated hydrolysis of stored cholesterol esters in atherosclerotic-lesion associated foam cells contributes to decreased cholesterol efflux capacity of serum HDL particles in patients with atherosclerosis or risk for atherosclerosis and is associated with decreased vascular endothelial function. The present research proposal aims to assess cholesterol efflux potential of serum, and its relationship to ApoAI / ApoAII ratio of HDL particles, monocyte/macrophage CEH expression and vascular endothelial function. This will be a cross-sectional pilot study investigating cholesterol efflux potential, ApoAI / ApoAII ratio, cholesterol ester hydrolysis expression, and endothelial function in three groups.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该研究的假设：动脉粥样硬化与泡沫细胞中储存的胆固醇酯的水解减弱，有助于动脉粥样硬化或动脉粥样硬化患者的血清HDL颗粒的胆固醇外排能力降低，并导致患有降低血管内皮性内皮性内皮性内皮性内皮性内皮性。 本研究建议旨在评估血清的胆固醇外排潜能，以及其与HDL颗粒，单核细胞 /巨噬细胞CEH表达和血管内皮功能的APOAI / APOAII比率的关系。 这将是一项横断面试验研究，研究胆固醇外排势，ApoAI / ApoAII比，胆固醇酯水解表达和三组内皮功能。