FASEB Summer Conference on Nuclear Structure and Cancer

FASEB 核结构与癌症夏季会议

• 批准号: 7426335
• 负责人: David G. Kaufman
• 金额: $ 0.75万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2010-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7426335
• 关键词: Academia; Academy; Address; American; Animal Model; Architecture; Arts; Biochemical; Biological; Biology; Cell Nucleus; Cells; Clinical; Clinical Investigator; Educational workshop; Epigenetic Process; Funding; Gene Expression Regulation; Genes; Genomics; Interphase; Life; Malignant Neoplasms; Methodology; Molecular Genetics; Morphology; Nuclear; Nuclear Import; Nuclear Structure; Nucleic Acids; Private Sector; Process; Property; Research; Research Personnel; Resolution; Rivers; Role; Societies; Tumor Cell Nuclei; Vermont; abstracting; cancer cell; cancer diagnosis; combinatorial; genetic regulatory protein; in vivo; innovation; insight; meetings; molecular imaging; multidisciplinary; novel; posters; repaired; symposium; trafficking; tumor; tumor progression

DESCRIPTION (provided by applicant): This application is for partial funding of the fourth and fifth FASEB Summer Research Conferences on "Nuclear Structure and Cancer" that will be held June 16-21, 2007 and in 2009, at the Vermont Academy in Saxtons River, Vermont. The conferences are under the auspices of the Federation of American Societies for Experimental Biology (FASEB). For both conferences, there will be 9 platform sessions, a workshop on molecular imaging in living cells and animal models and two poster sessions. Young investigators will be encouraged to give short talks at the regular platform and workshop sessions by selection from the submitted abstracts. The meetings will bring together basic and clinical investigators from academia and the private sector to focus on understanding the role of altered nuclear structure in the cancer process. These conferences will provide forums to evaluate the fundamental regulatory and clinical implications of modified temporal and spatial organization of nucleic acids and regulatory proteins that control gene replication, repair and expression in nuclei of tumor cells. The study of tumor-related changes in nuclear morphology and the subnuclear organization, nuclear import, intranuclear trafficking and assembly of regulatory factors is becoming increasingly relevant from both basic biological and clinical perspectives. There is a need for this conference that is dedicated to examining the structural and functional properties of the interphase nucleus in cells that are structurally and functionally compromised with the onset and progression of cancer. Mechanisms that interrelate nuclear morphology with gene replication, repair and expression will be systematically explored. There will be a concerted effort to critically evaluate emerging findings that interface nuclear organization with the assembly of regulatory machinery that governs the combinatorial control of genomic function. Epigenetic regulatory mechanisms will be addressed. Consideration will be given to contributions from cellular, biochemical, in vivo genetic and molecular approaches and their integration into multidisciplinary strategies for understanding the interrelationships among genomic organization, function, and cancer. Relevance: The objective of these meetings will be to develop experimental agendas that incorporate novel concepts and high resolution state-of-the-art methodologies for defining perturbations in nuclear architecture that are related to changes in the regulation of gene replication, repair, and expression in cancer cells. It is realistic to anticipate insight into components of nuclear organization that can be selectively targeted for innovative cancer diagnosis and therapy.

说明（由申请人提供）：本申请为第四届和第五届 FASEB 夏季研究会议“核结构与癌症”提供部分资助，该会议将于 2007 年 6 月 16 日至 21 日和 2009 年在萨克斯顿河的佛蒙特学院举行，佛蒙特州。这些会议由美国实验生物学会联合会 (FASEB) 主办。两次会议均将举办 9 场平台会议、一场活细胞和动物模型分子成像研讨会以及两场海报会议。将鼓励年轻研究人员通过从提交的摘要中进行选择，在定期平台和研讨会上进行简短的演讲。这些会议将汇集来自学术界和私营部门的基础和临床研究人员，重点了解核结构改变在癌症过程中的作用。这些会议将提供论坛来评估控制肿瘤细胞核中基因复制、修复和表达的核酸和调节蛋白的改进的时间和空间组织的基本调节和临床影响。从基础生物学和临床角度来看，与肿瘤相关的核形态和亚核组织变化、核输入、核内运输和调节因子组装的研究变得越来越重要。这次会议有必要专门研究细胞间期核的结构和功能特性，这些细胞在结构和功能上与癌症的发生和进展有关。将系统地探索核形态与基因复制、修复和表达之间的相互关联机制。我们将齐心协力，批判性地评估将核组织与控制基因组功能组合控制的调控机制结合起来的新发现。表观遗传调控机制将得到解决。将考虑细胞、生物化学、体内遗传和分子方法的贡献，并将它们整合到多学科策略中，以了解基因组组织、功能和癌症之间的相互关系。 相关性：这些会议的目标是制定实验议程，其中纳入新颖的概念和高分辨率最先进的方法，用于定义与基因复制、修复和表达调控变化相关的核结构扰动在癌细胞中。预测对核组织组成部分的深入了解是现实的，这些组成部分可以选择性地针对创新的癌症诊断和治疗。