PERIPHERAL ARTERIAL DISEASE AND LEG MUSCLE METABOLISM

外周动脉疾病与腿部肌肉代谢

• 批准号: 7605381
• 负责人: LOIS A KILLEWICH
• 金额: $ 2.83万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605381
• 关键词: Affect; Age; American; Amino Acids; Arterial Occlusive Diseases; Blood flow; Bypass; Computer Retrieval of Information on Scientific Projects Database; Condition; Funding; Grant; Impairment; Institution; Intervention; Lead; Leg; Limb structure; Lower Extremity; Medical; Methodology; Methods; Muscle; Muscle Proteins; Oral; Peripheral; Peripheral arterial disease; Population; Protein Biosynthesis; Quality of life; Recovery; Research; Research Personnel; Resources; Source; Supplementation; United States; United States National Institutes of Health; Walking; improved; muscle metabolism; protein metabolism; research study; response; sarcopenia; stable isotope

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Peripheral arterial occlusive disease (PAOD) is a common, disabling medical condition which affects 1% of the United States population 55 years old, resulting in impaired walking ability, limb loss, and reduced functional independence. Older Americans are also subject to "sarcopenia," a condition in which lower extremity muscle mass and function declines with age. The combination of sarcopenia and reduced blood flow make older subjects with PAOD particularly vulnerable to walking impairments, reduced independence, and a poorer quality of life. The hypothesis of this study is that improved blood flow together with oral amino acid supplementation to treat sarcopenia will result in improved protein metabolism in older PAOD subjects. Subjects with PAOD will undergo prebypass quantification of leg protein metabolism before and after amino acid supplementation using stable isotope methodology. They will then undergo lower extremity bypass, and after the immediate recovery period, leg protein metabolism before and after amino acid supplementation will be restudied to determine if improved blood flow augments the response. The significance of this research study is that it assesses the benefit of the two interventions of leg revascularization and amino acid supplementation in improving leg muscle protein synthesis in older subjects witih PAOD. Ultimately, we hope this will lead to methods for improving walking ability and quality of life in these subjects.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 外围动脉闭塞性疾病（PAOD）是一种常见的，残疾的医疗状况，影响了55岁的美国人口的1％，导致步行能力受损，肢体损失和功能独立性降低。 年长的美国人还受到“肌肉减少症”的约束，这种情况下下肢肌肉质量和功能随着年龄的增长而下降。 肌肉减少症和减少血流的结合使较老的受试者与PAOD特别容易受到步行障碍的影响，独立性降低和生活质量较差。 这项研究的假设是，改善的血液流量以及补充口服氨基酸以治疗肌肉减少症，将改善较老的PAOD受试者的蛋白质代谢。 患有PAOD的受试者将使用稳定的同位素方法进行氨基酸补充之前和之后的腿蛋白代谢的典型定量。 然后，他们将经历下肢旁端，在即时恢复期后，补充氨基酸之前和之后的腿部蛋白质代谢将被重新确定，以确定改善的血液流量是否增加了反应。 这项研究的意义在于，它评估了腿部血运重建和补充氨基酸的两种干预措施在改善老年受试者中的腿部肌肉蛋白合成方面的益处。 最终，我们希望这将导致改善这些学科的步行能力和生活质量的方法。