Drug Releasing Microdiscs for Esophageal Drug Delivery

用于食管药物输送的药物释放微盘

基本信息

批准号：
9903414
负责人：
Rachel Chevalier
金额：
$ 7.5万
依托单位：
CHILDREN'S MERCY HOSP (KANSAS CITY, MO)
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9903414
关键词：
Address Adrenal Cortex Hormones Affect Alginates Amino Acids Area Biological Availability Biomedical Engineering Budesonide Child Childhood Chitosan Chocolate Clinical Controlled Environment Deglutition Development Disease Disease Outcome Dose Drug Delivery Systems Drug Targeting Eosinophilic Esophagitis Epithelial Epithelium Esophageal Stenosis Esophagus Excipients Exhibits Exposure to FDA approved Failure Failure to Thrive Film Food Aversion Force of Gravity Formulation Future Gastroenterologist Gastrointestinal tract structure Goals Healthcare High Pressure Liquid Chromatography Honey Humidity Individual Industry Infant formula Inflammatory Intestines Knowledge Lead Length Masks Measures Methodology Methods Microfabrication Morbidity - disease rate Mucous Membrane Oral Palate Pathology Patients Pattern Peristalsis Pharmaceutical Preparations Pharmacologic Substance Pharmacotherapy Physicians Physiological Physiology Polymers Property Saliva Seaweed Semiconductors Shapes Silicon Site Sodium Steroids Surface Suspensions Taste Perception Techniques Temperature Therapeutic Thinness Time Tissues Toxic effect Training Work base biocompatible polymer biomaterial compatibility chronic inflammatory disease clinical practice controlled release cost design effective therapy fluticasone improved in vivo manufacturing process novel novel therapeutics off-label use pediatric patients residence side effect standard of care success targeted treatment uptake

项目摘要

PROJECT SUMMARY: Eosinophilic esophagitis (EoE) is an inflammatory disease affecting children at an increasing rate leading to failure to thrive, esophageal stricturing, and the need for long term healthcare. Off-label use of topical steroids is the mainstay of treatment, but a high failure rate and clinical concerns of palatability have necessitated physicians using unstudied grocery items as excipients. The goal of this proposal is to investigate the properties of current empiric therapies and use that knowledge to develop a microscale polymer disc (microdiscs) designed to improve residence time of drug therapy in the esophagus. Microdiscs are designed to prolong drug residence time in the esophagus and have controlled-release properties to increase mucosal exposure to drug, thus delivering drug directly to the target site of EoE. The prolonged residence time of the mucoadhesive discs will be expected to improve bioavailability which decreases patient exposure to steroids, decreases costs, and opens new possibilities for other pharmaceutical treatments with fewer side effects to be delivered in the same manner.

项目概要：嗜酸性粒细胞性食管炎（EoE）是一种影响儿童的炎症性疾病速率增加导致发育迟缓、食管狭窄以及需要长期治疗卫生保健。超说明书使用外用类固醇是主要治疗方法，但失败率很高临床上对适口性的担忧使得医生必须使用未经研究的杂货作为赋形剂。该提案的目标是研究当前经验的属性疗法并利用这些知识开发设计的微型聚合物盘（microdisc）以改善药物治疗在食道中的停留时间。微盘旨在延长药物在食道的停留时间并具有控释特性，以增加粘膜暴露于药物，从而将药物直接递送至 EoE 的靶位点。延长的粘膜粘附盘的停留时间预计将提高生物利用度减少患者对类固醇的接触，降低成本，并为其他治疗开辟新的可能性以同样的方式进行副作用较少的药物治疗。