OMEGA 3 FATTY ACIDS: ANTI-INFLAMMATORY PROPERTIES AND INFLUENCE ON C-REACTIVE PR

OMEGA 3 脂肪酸：抗炎特性及其对 C 反应性 PR 的影响

• 批准号: 7605973
• 负责人: SUSAN K RAATZ
• 金额: $ 0.86万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605973
• 关键词: Anti-Inflammatory Agents; Anti-inflammatory; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Daily; Dietary Supplementation; Elevation; End Point; Exhibits; Fish Oils; Funding; Grant; Individual; Inflammation; Inflammatory; Institution; Laboratories; Measures; Omega-3 Fatty Acids; Oxidative Stress; Participant; Placebos; Process; Property; Randomized; Recruitment Activity; Research; Research Personnel; Resources; Risk; Risk Factors; Screening procedure; Source; United States National Institutes of Health; Visit; Woman; capsule; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will be assessing whether dietary supplementation with omega 3 fatty acid (fish oil) will reduce inflammation in individuals with a high risk profile for cardiovascular disease without an elevation on oxidative stress. Twenty men and women who are healthy but exhibit elevated risk factors for cardiovascular disease will be recruited as participants. Subjects will be randomly assigned to receive fish oil or placebo capsules daily for a 4-month period. Measures of oxidative stress and inflammatory processes will be determined at baseline, 2 and 4 months. In order to accomplish this project, the GCRC will be utilized for screening and endpoint mesurement visits. The GCRC GC/MS laboratory will be required for determination of 8-iso PGF2a, a measure of oxidative stress.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将评估饮食中补充欧米茄3脂肪酸（鱼油）是否会减少心血管疾病风险高的人的炎症，而没有氧化应激的升高。 将招募20名健康但患有心血管疾病的危险因素的男人和女性将被招募为参与者。 每天4个月内，将随机分配受试者每天接收鱼油或安慰剂胶囊。 氧化应激和炎症过程的度量将在基线，2和4个月时确定。 为了完成该项目，将使用GCRC进行筛选和端点介绍访问。 确定8-ISO PGF2A（氧化应激度量）需要GCRC GC/MS实验室。