A behavioral trial for parents of childhood cancer survivors with neurobehavioral

针对患有神经行为的儿童癌症幸存者父母的行为试验

基本信息

批准号：
7615721
负责人：
Sunita K Patel
金额：
$ 8.3万
依托单位：
BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-18 至 2010-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7615721
关键词：
Address Adherence Behavior Behavioral Cancer Survivor Caregivers Central Nervous System Diseases Child Clinic Clinical Trials Design Cognitive Control Groups Cranial Irradiation Data Diagnosis Educational Intervention Exercise Frequencies Functional disorder Home environment Intervention Intrathecal Chemotherapy Investigation Knowledge Late Effects Learning Malignant Childhood Neoplasm Malignant Neoplasms Manuals Measures NIH Program Announcements Neuraxis Neurocognitive Outcome Parenting behavior Parents Performance Pilot Projects Randomized Controlled Trials Research Risk Route Schools Stress Survivors Telephone Testing Therapeutic Therapeutic Intervention Time Training Waiting Lists base childhood cancer survivor design improved innovation interest intervention program neurobehavioral post intervention programs remediation response skills skills training standardize measure success teacher treatment as usual

项目摘要

DESCRIPTION (provided by applicant): More than 50% of children diagnosed with cancer are at risk for adverse neurocognitive changes due to central nervous system (CNS) disease and/or CNS directed therapy, such as cranial radiation and intrathecal chemotherapy. While there are a large number of studies to identify and quantify the adverse neurobehavioral impact of childhood cancer, empirical investigations of therapeutic interventions to treat such sequelae are only now emerging. The current proposed study, in response to a Program Announcement for quality of cancer survival, represents an important step in advancing the research to improve and manage neurocognitive and behavioral late effects in childhood cancer survivors with CNS-directed therapy. The study is innovative in that it diverges from the recent, child directed remediation efforts based in the clinic, which thus far have yielded limited and only small benefits, and instead explores the potential of a different route to positively influence child outcomes. The study pilots a behavioral trial to empirically evaluate the impact of a parent intervention for the primary purpose of improving the child's academic, cognitive, and behavioral functioning. We have developed a training manual for our parent intervention that addresses four basic parenting components important to promote learning and school success in the child. We will evaluate the feasibility of implementing our program, track adherence, and collect preliminary data on the impact. Project Relevance: This study is expected to increase knowledge about whether specific parenting activities may positively impact learning and school performance in children treated with CNS-directed therapy and who have neurocognitive and behavioral/adaptive difficulties.

描述（由申请人提供）：超过50％的被诊断为癌症的儿童因中枢神经系统（CNS）疾病和/或CNS定向治疗而受到不良神经认知的风险，例如颅放射和胸膜内化学疗法。尽管有大量的研究可以识别和量化儿童癌症的不良神经行为影响，但治疗这种后遗症的治疗干预措施的经验研究直到现在才出现。当前提出的研究回应了癌症生存质量的计划公告，这是促进研究中CNS指导治疗的儿童癌症幸存者的神经认知和行为后期影响的重要一步。这项研究具有创新性，因为它与最近的基于诊所的近期指导的补救工作不同，到目前为止，该工作已经有限，只有很小的益处，而是探索了另一条不同途径的潜力，从而积极影响儿童的结果。研究飞行员一项行为试验，以经验评估父母干预的影响，以改善孩子的学术，认知和行为功能。我们已经为我们的父母干预开发了一份培训手册，该手册解决了四个基本的育儿组成部分，这对于促进孩子的学习和学校成功很重要。我们将评估实施计划，跟踪依从性并收集有关影响的初步数据的可行性。项目相关性：预计这项研究将增加有关特定育儿活动是否会对接受中枢神经系统指导治疗以及具有神经认知和行为/适应性困难的儿童的学习和学校表现的知识。