Ohio Valley Node-Network (OVNN) of the NIDA Clinical Trials Network

NIDA 临床试验网络的俄亥俄谷节点网络 (OVNN)

• 批准号: 9905868
• 负责人: T John WINHUSEN
• 金额: $ 245.75万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9905868
• 关键词: Accident and Emergency department; Address; Adopted; Adoption; Advocate; Alcohol or Other Drugs use; Appalachian Region; Award; Buprenorphine; Caring; Clinical; Clinical Practice Guideline; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Conduct Clinical Trials; Cultural Diversity; Data; Education; Elderly; Electronic Health Record; Emergency Medicine; Epidemic; Geography; Goals; HIV/HCV; Health Personnel; Indiana; Individual; Institution; Intervention; Intervention Trial; Leadership; Link; Medical; Mississippi; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; Native Americans; Ohio; Overdose; Patients; Pharmacy facility; Policies; Practice based research; Pragmatic clinical trial; Primary Health Care; Productivity; Property; Provider; Public Health; Recording of previous events; Research; Research Personnel; Site; Substance Use Disorder; Testing; U-Series Cooperative Agreements; Vision; Wisconsin; Work; addiction; base; clinical practice; clinical research site; disorder prevention; driving force; experience; implementation research; innovation; member; multi-site trial; novel; opioid abuse; opioid misuse; opioid overdose; pediatric emergency; peer; practice setting; practice-based research network; prevent; screening and brief intervention; screening, brief intervention, referral, and treatment; statistics; transmission process

Project Summary-Abstract: Since its establishment in 2000, the Ohio Valley Node (OVN) has been one of the most productive of NIDA's Clinical Trials Network (CTN) nodes, both in leading and participating in multi-site trials. In this application the OVN has been expanded to be a node of networks: the Ohio Valley Node-Network (OVNN). The OVNN includes eight original OVN sites, which are located in 6 states and treat more than 225,000 patients per year; and three additional practice based research networks (PBRNs). Two are state-wide primary care PBRNs, the Collaborative Ohio Inquiry Network (COIN) and the Wisconsin Research and Education Network (WREN), which, combined, include more than 350 practices and treat more than 4 million patients per year. The third is a state-wide pharmacy PBRN in Indiana, which includes 168 pharmacies that fill 1.5 million prescriptions annually. These Midwestern sites and partnerships will contribute needed diversity to CTN clinical trials. The OVNN Research Core is the driving force of the OVNN and is led by Dr. Winhusen, one of the foremost experts in conducting multi-site addiction clinical trials in clinical practice settings. The OVNN co-investigators include experts in primary care (Elder), emergency medicine (Lyons), and pediatric emergency medicine (Grupp- Phelan) practice-based research. The 7 members of the OVN research-implementation team bring 72 years of combined experience conducting CTN clinical trials. A primary goal of the application is to conduct the research needed to inform clinical practice guidelines for effective substance use disorder (SUD) prevention and treatment in general medical care settings, which are largely lacking but increasingly needed, with a specific focus on research to address the opioid abuse epidemic. Our proposed research agenda includes pragmatic clinical trials testing interventions to predict, prevent, and respond to opioid misuse in primary care; to reduce the reoccurrence of opioid overdose by linking patients treated for an overdose in emergency medicine departments to SUD treatment through a novel peer-based intervention; and to reduce the transmission of HIV and HCV through pharmacy-based testing for buprenorphine-treated patients.

项目摘要-摘要： 自 2000 年成立以来，俄亥俄谷节点 (OVN) 一直是 NIDA 中生产力最高的节点之一 临床试验网络 (CTN) 节点，领导和参与多中心试验。在此应用程序中 OVN 已扩展为网络节点：俄亥俄谷节点网络 (OVNN)。 OVNN 包括 OVN 最初的 8 个站点位于 6 个州，每年治疗超过 225,000 名患者；和三个 其他基于实践的研究网络（PBRN）。其中两个是全州初级保健 PBRN， 俄亥俄州合作调查网络 (COIN) 和威斯康星州研究与教育网络 (WREN)， 这些诊所总共包括 350 多个诊所，每年治疗超过 400 万患者。第三个是 印第安纳州的一家全州药房 PBRN，其中包括 168 家药房，可提供 150 万张处方 每年。这些中西部站点和合作伙伴关系将为 CTN 临床试验提供所需的多样性。这 OVNN 研究核心是 OVNN 的驱动力，由最重要的专家之一 Winhusen 博士领导 在临床实践环境中进行多中心成瘾临床试验。 OVNN 联合研究人员包括 初级保健（老年）、急诊医学（里昂）和儿科急诊医学（Grupp- Phelan）基于实践的研究。 OVN研究实施团队的7名成员带来了72年的经验 结合进行 CTN 临床试验的经验。该应用程序的主要目标是进行 需要研究为有效预防物质使用障碍（SUD）的临床实践指南提供信息 和一般医疗保健机构中的治疗，这在很大程度上缺乏但日益需要， 特别关注解决阿片类药物滥用流行问题的研究。我们提出的研究议程包括 实用的临床试验测试干预措施，以预测、预防和应对初级保健中阿片类药物滥用； 通过将紧急情况下接受过量治疗的患者联系起来，减少阿片类药物过量的再次发生 医学部门通过新颖的同伴干预来进行 SUD 治疗；并减少 通过对接受丁丙诺啡治疗的患者进行基于药房的检测来传播艾滋病毒和丙型肝炎病毒。