Digital Imaging Processing Core

数字图像处理核心

• 批准号: 7214539
• 负责人: Charles Raymond Meyer
• 金额: $ 30.89万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214539
• 关键词: Administrator; Amendment; Animals; Archives; Authorization documentation; Back; Biological Markers; Budgets; Cell Line; Cells; Clinical Trials; Data; Data Set; Data Storage and Retrieval; Databases; Development, Other; Diffusion; Direct Costs; Disclosure; Equipment; Fees; Freedom; Funding; Future; Goals; Head; Health; Histology; Human; Human Resources; Image; Image Analysis; Implant; Inpatients; Instruction; Investigation; Last Name; Lead; Lesion; Location; Magnetic Resonance Imaging; Maintenance; Malignant neoplasm of brain; Maps; Methods; Michigan; Modeling; Multimodal Imaging; Names; Noise; Numbers; Outpatients; Patient Care; Patients; Perfusion; Positioning Attribute; Principal Investigator; Protocols documentation; Publishing; Registries; Research; Research Personnel; Resolution; Role; Sampling; Scanning; Slice; Software Tools; Specific qualifier value; System; TAF8 gene; Techniques; Testing; Therapeutic; Translating; Travel; Universities; Wages; Weight; analytical tool; base; cost; data integrity; digital imaging; falls; human embryonic stem cell; human study; image processing; image registration; in vivo; method development; programs; response; size; tool; tumor

Core C: Digital Image Processing The goals of the Digital Image Processing Core are to continue provide analytic tools for all projects. These unique image analysis tools are necessary for unbiased, accurate, quantitative analysis of temporal volumetric changes in single and multimodal MRI data sets of lab animals and human patients. Currently all MRI acquisitions independent of weightings for all interval exams of both animal and human studies are fully automatically registered to a "reference" data set in the first exam typically using a rotate- translate geometry model; this is a multimodality registration problem using existing software tools. Typically a T1-weighted, post-Gad sequence, is used as the reference for registering all successive interval exam sets. B1-field corrections have been found to be unnecessary thus far. In cases where the acquisitions involve high gradient fields such as those used for diffusion or perfusion weighted imaging, registrations are accomplished using a full affine model to support correction of shears caused by the gradients. Currently all human scan data including both original acquisitions and registered datasets, as well as animal backups, are stored on the Core's disk system. In the future all animal scans will be likewise stored on the Core's disks which can be accessed via TCP/IP or SAMBA protocols over 100 Mb ethernet. Of course the Core is responsible for maintaining data integrity and backup. The core will also develop the ability to track the positions of voxels within treated lesions across interval exams using high degree of freedom warpings. This facility for both animal and human imaging will support further investigation of the role of the apparent diffusion coefficient (ADC) as well as other parameters, e.g. perfusion, as potentially early indicators of therapeutic response. Additionally in the A1 amendment this Core demonstrated the ability to map histology back to in vivo MRI voxels for animals (where whole head ex vivo MRI acquisitions are possible) using only intrinsic scan information (i.e. no implanted fiducials of any kind). Pub. Health: Overall, this research effort willprovide therationale for initiation of clinical trials with combinations of molecularly targeted therapies for the treatment of malignant brain tumors. In addition, imaging biomarkers for early assessment of treatment response will be identified and validated which will lead to individualization of patient treatment. University of Michigan Ann Arbor, Michigan PHS 398(Rev. 09/04) Page 3/V Form Page 2 Principal Investigator/Program Director (Last, First, Middle): ROSS, Brian D. KEY PERSONNEL. See instructions. Usecontinuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name eRA Commons User Name Organization Role on Project Meyer, Charles Cmeyer University of Michigan Core Director Bland, Peyton University of Michigan Co-Investigator OTHER SIGNIFICANT CONTRIBUTORS Name Organization Role on Project Human Embryonic Stem Cells ^ No [~1 Yes If the proposed project involves human embryonic stem cells, list below the registration number of the specific cell llne(s) from the following list: http://stemcells.nih.gov/reaistrv/index.asp. Usecontinuationpages asneeded. If a specific line cannot be referenced at thistime, includea statement that one from the Registry will be used. Cell Line Disclosure Permission Statement Applicable toSBIR/STTR Onlv. See SBIR/STTR instructions. Q Yes Q No PHS 398 (Rev. 09/04) Page 31$" Form Page 2-continued Number the following pages consecutively throughout the application. Do not use suffixes such as 4a, 4b. Principal Investigator/Program Director (Last, first, middle): DETAILED BUDGET FOR INITIAL BUDGET PERIOD DIRECT COSTS ONLY Meyer/Core C PERSONNEL (Applicant organization only) % TYPE EFFORT INST. ROLE ON APPT. ON BASE NAME PROJECT (months) PROJ. SALARY Core Meyer, Charles Director 12 15% $160,680 Co-lnv. Bland, Peyton 12 25% $95,790 System Laderach, Gary Administrator 12 5% $71,028 Programmer Geng, Hairong Analyst 12 100% $53,250 Programmer (TBN) Technical 12 100% $50,000 GSRA Eng. GSRA (TBN) 12 100% $23,422 SUBTOT0.1 " "^ CONSULTANT COSTS EQUIPMENT (Itemize) Purchased in Years 2 & 3 SUPPLIES (Itemize bycategory) Mag Tape $500 TRAVEL 1 -2 Trips/year for Core Director PATIENT CARE COSTS INPATIENT OUTPATIENT ALTERATIONS AND RENOVATIONS (Itemize bycategory) OTHER EXPENSES (Itemize bycategory) GSRA Tuition & Fees $14,772 (Fall & Winter) Maintenance Fees $3,000 CONSORTIUM/CONTRACTUAL COSTS Ross, Brian D. FROM THROUGH 12/1/2006 11/30/2007 DOLLAR AMOUNT REQUESTED (omit cents) SALARY FRINGE . REQUESTED BENEFITS TOTALS $24,102 $7,231 $31,333 $23,948 $7,184 $31,132 $3,551 $1,065 $4,616 $53,250 $15,975 $69,225 $50,000 $15,000 $65,000 $23,422 $7,027 $30,449 $178,273 $53,482 $231,755 I $500 $1,200 $17,772 DIRECT COSTS SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PEF (Item 7a, FacePage) $ 251,227 CONSORTIUM/CONTRACTUAL COSTS | FACILITIES AND ADMINISTRATION COSTS! TOTAL DIRECTCOSTS FOR INITIAL BUDGET PERIOD $ I * 251 ,227 | SBIR/STTR Only: FEE REQUESTED PHS 398 (Rev. 09/04) Page Form Page 4

核心C：数字图像处理 数字图像处理核心的目标是继续为所有项目提供分析工具。这些 独特的图像分析工具对于时间上的公正，准确，定量分析是必需的 实验室动物和人类患者的单模式MRI数据集的体积变化。 目前，所有MRI获取都独立于权重的所有间隔检查，均可进行动物和人类 研究通常会自动注册为第一次考试中通常使用旋转的“参考”数据集 翻译几何模型；这是使用现有软件工具的多模式注册问题。通常 T1加权后加德序列被用作注册所有连续间隔检查的参考 套。到目前为止，已经发现B1场校正是不必要的。在收购的情况下 涉及高梯度领域，例如用于扩散或灌注加权成像的梯度，注册为 使用完整的仿射模型完成了支持梯度引起的剪切的校正。目前全部 人类扫描数据包括原始收购和注册数据集以及动物备份 stored on the Core's disk system.将来，所有动物扫描都将同样存储在核心磁盘上 可以通过TCP/IP或SAMBA协议访问100 MB以太网。当然核心是 负责维护数据完整性和备份。 核心还将发展能够跟踪跨间隔治疗病变中体素位置的位置 使用高度自由度交易的考试。动物和人类成像的设施都将支持 进一步研究明显扩散系数（ADC）以及其他参数的作用，例如 灌注，作为治疗反应的潜在早期指标。此外，在A1修正案中 核心证明了将组织学映射回动物体内MRI体素的能力（整个头部 可能仅使用固有的扫描信息（即，任何任何植入的基金会 种类）。 酒吧健康：总的来说，这项研究工作将介绍用于启动临床试验的情况 分子靶向疗法用于治疗恶性脑肿瘤的组合。此外， 将确定和验证成像生物标志物，用于早期评估治疗反应，这将 导致个性化患者治疗。 密歇根大学 密歇根州安阿伯 PHS 398（Rev。09/04）第3页/V表格2 首席调查员/计划主任（最后，第一，中间）：罗斯，布莱恩·D。 关键人员。请参阅说明。根据需要提供的用户访问页面，以下面显示的格式提供所需的信息。 从首席研究员开始。按字母顺序列出所有其他关键人员，首先姓氏。 名称ERA CONSONS用户名组织在项目中的角色 迈耶，查尔斯·塞米耶大学密歇根大学核心董事 布兰德，密歇根大学佩顿大学共同研究员 其他重要的贡献者 姓名组织角色 人类胚胎干细胞 ^否[〜1是 如果提出的项目涉及人类胚胎干细胞，则从以下列表中列出了特定细胞LLNE的注册号以下： http://stemcells.nih.gov/reaistrv/index.asp。 USECONTINUATIONPAGES已累及。 如果此时无法引用特定行，则包括将使用注册表中的一条线。 细胞系 披露许可声明适用Tosbir/sttr Onlv。请参阅SBIR/STTR说明。 Q是Q否 PHS 398（Rev. 09/04）页31 $“表格第2页） 在整个过程中连续编号以下页面 应用程序。请勿使用4A，4B等后缀。 首席调查员/计划主管（最后，第一，中间）： 初始预算期的详细预算 直接费用仅Meyer/Core C 人员（仅申请人组织）％ 类型努力Inst。 角色 appt。在基础上 名称项目（月）Proj。薪水 核 迈耶，查尔斯董事12 15％$ 160,680 共同体 Bland，Peyton 12 25％$ 95,790 系统 Laderach，加里管理员12 5％$ 71,028 程序员 Geng，Hairong分析师12 100％$ 53,250 程序员 （TBN）技术12 100％$ 50,000 GSRA 工程。 GSRA (TBN) 12 100% $23,422 subtot0.1“”^ 顾问费用 设备（逐项） 在2和3年份购买 供应（逐项字节） 磁带$ 500 旅行 核心董事每年1 -2次旅行 患者护理费用住院 门诊 更改和翻新（逐项计算） 其他费用（逐项字节） GSRA学费和费用$ 14,772（秋冬） 维护费$ 3,000 财团/合同费用 罗斯，布莱恩·D。 从通过 2006年12月1日11/30/2007 要求的美元金额（省略美分） 薪水附带。 要求的福利总计 $ 24,102 $ 7,231 $ 31,333 $ 23,948 $ 7,184 $ 31,132 $ 3,551 $ 1,065 $ 4,616 $ 53,250 $ 15,975 $ 69,225 $50,000 $15,000 $65,000 $ 23,422 $ 7,027 $ 30,449 $ 178,273 $ 53,482 $ 231,755 i $ 500 $ 1,200 $ 17,772 直接成本 初始预算PEF（项目7A，面页）$的次序直接费用$ 251,227 财团/合同费用|设施和管理费用！ 初始预算期间的总直接限额$ i * 251，227 | 仅SBIR/STTR：要求收费 PHS 398（修订版09/04）页面4页