Comparative Effectiveness Research and Patient Reported Outcomes in Diverticulitis

憩室炎的比较有效性研究和患者报告的结果

基本信息

批准号：
9492714
负责人：
anne peery
金额：
$ 19.36万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9492714
关键词：
Abdomen Abdominal Pain Acute Address Admission activity Adverse effects Affect Americas Amoxicillin Anorexia Antibiotic Therapy Antibiotics Award Chronic Clavulanate Clinical Clinical Sciences Cognitive Cohort Studies Communicable Diseases Constipation Data Data Set Development Diarrhea Digestive System Disorders Disease Diverticulitis Diverticulum Drug Approval Effectiveness Ensure Environment Epidemiology Escherichia coli Faculty Fever Fluoroquinolones Funding Future Gastroenterologist Gastrointestinal Diseases Goals Guidelines Health Care Costs Health Expenditures Hospitals Inflammation Institution Intervention Intervention Studies Interview Intestines Knowledge Medical Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Meta-Analysis Methods Metronidazole North Carolina Operative Surgical Procedures Outcome Outcome Measure Outcomes Research Outpatients Pain Patient Outcomes Assessments Patients Peer Review Pharmacoepidemiology Physicians Population Prevention trial Principal Investigator Privatization Productivity Public Health Publications Qualitative Research Quality of life Recommendation Recurrence Regimen Research Research Methodology Research Personnel Research Project Grants Research Training Resistance Risk Scientist Series Societies Solid Symptoms Tissues Training Translational Research United States National Institutes of Health Universities Visit Writing associated symptom career career development common treatment comparative effectiveness design disorder later incidence prevention effectiveness research evidence base experience gastrointestinal gastrointestinal symptom health care service utilization higher education instrument member novel patient oriented research relative effectiveness skills standard of care symposium treatment trial

项目摘要

PROJECT SUMMARY This is an application for a three-year mentored patient-oriented research career development award (K23). The overall goals are to 1) contribute to our understanding about the effectiveness, benefits and harms of antibiotics for acute diverticulitis and to develop a novel acute diverticulitis specific patient reported outcome measure through patient-oriented research; 2) educate and mentor the candidate clinician investigator while she transitions to independence. The candidate is a motivated clinical researcher at the University of North Carolina Chapel Hill with a background in digestive disease epidemiology and a solid publication record. The mentoring team includes an expert in gastrointestinal epidemiology (Sandler), pharmacoepidemiology and comparative effectiveness research (Sturmer) and patient reported outcome measures (Basch). Each member of the mentoring team has an established record of mentoring junior faculty, high research productivity, and substantial peer-reviewed support. The research and training environment at the University of North Carolina Chapel Hill is strong and well established. For fiscal year 2015, the University of North Carolina at Chapel Hill ranked ninth among both private and public universities nationwide for National Institutes of Health (NIH) research funding to domestic institutions of higher education. The candidate’s career development objectives are as follows: 1) to develop the knowledge and experience needed to perform analytic studies using large datasets with an emphasis on pharmacoepidemiology and comparative effectiveness research; 2) to develop knowledge and experience in patient-reported outcomes measures; 3) to transition to independence. To achieve these goals, the candidate will: 1) participate in advanced, graduate level coursework and conferences in pharmacoepidemiology, comparative effectiveness research and patient reported outcome measures; 2) attend The North Carolina Translational & Clinical Sciences Principal Investigator Development Series and join the R-Writing Group; 3) conduct mentor guided research. The specific aims of the research project are: 1) To evaluate the comparative effectiveness of antibiotic therapy with a combination a fluoroquinolone and metronidazole compared to amoxicillin-clavulanate alone for a first occurrence of medically managed outpatient acute diverticulitis on recurrence and complications using administrative claims data; 2) To develop an acute diverticulitis specific patient reported outcome measure: a) To identify the symptom domains relevant to patients with acute diverticulitis using qualitative research methods; b) To select items for an acute diverticulitis specific patient reported outcome measure using existing PRO instruments; c) To perform cognitive interviews with patients with acute diverticulitis to ensure content validity. The support and mentorship provided by a K23 is critical to achieve the candidate’s goal of transitioning to an independent physician-scientist in the field of digestive diseases.

项目概要这是一份为期三年的以患者为指导的研究职业发展奖（K23）的申请。总体目标是 1) 有助于我们了解以下内容的有效性、益处和危害：抗生素治疗急性憩室炎并开发一种新型急性憩室炎特定患者报告的结果通过以患者为中心的研究进行衡量；2) 教育和指导候选临床医生研究者，同时她过渡到独立。候选人是北方大学一位积极进取的临床研究员。 Carolina Chapel Hill 拥有消化系统疾病流行病学背景和可靠的发表记录。指导团队包括胃肠道流行病学（Sandler）、药物流行病学和比较有效性研究（Sturmer）和患者报告的结果测量（Basch）。的导师团队拥有指导初级教师的良好记录、较高的研究生产力以及北卡罗来纳大学的大量同行评审支持。 2015 财年，教堂山分校实力雄厚、设施完善。美国国立卫生研究院 (NIH) 在全国私立和公立大学中排名第九向国内高等教育机构提供研究经费。如下： 1）发展使用大型数据进行分析研究所需的知识和经验 2) 开发侧重于药物流行病学和比较有效性研究的数据集；患者报告的结果测量方面的知识和经验；3) 过渡到独立。为了实现这些目标，候选人将：1）参加高级研究生水平课程和会议药物流行病学、比较有效性研究和患者报告的结果测量 2) 参加北卡罗来纳州转化与临床科学首席研究员发展系列并加入 R-Writing Group；3）进行导师指导的研究研究项目的具体目标是： 1）评估抗生素与氟喹诺酮类药物联合治疗的比较效果甲硝唑与单独使用阿莫西林克拉维酸治疗首次发生药物治疗的并发症的比较使用行政索赔数据评估门诊急性憩室炎的复发和并发症；急性憩室炎特定患者报告的结果测量： a) 确定相关症状领域使用定性研究方法对急性憩室炎患者进行选择；使用现有 PRO 仪器进行憩室炎特定患者报告的结果测量；对急性憩室炎患者进行认知访谈，以确保内容的有效性。 K23 提供的指导对于实现候选人过渡到独立的目标至关重要消化系统疾病领域的医师科学家。