Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in Ag

主观社会孤立和睡眠障碍：Ag 的炎症机制

• 批准号: 7728802
• 负责人: Michael R Irwin
• 金额: $ 37.88万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7728802
• 关键词: Adult; Age; Aging; Behavioral Symptoms; Biological; Biological Clocks; Biology; Body mass index; C-reactive protein; Cardiovascular Diseases; Characteristics; Clinical; Communities; Cytokine Gene; Cytokine Network Pathway; Demographic Factors; Depressed mood; Development; Diabetes Mellitus; Disease; Disease Outcome; Elderly; Emotional; Epidemiologic Studies; Fatigue; Feeling; Fingerprint; Gender; Genes; Genomics; Health; Human; Inflammation; Inflammatory; Inflammatory Response; Interdisciplinary Study; Interleukin-6; Laboratory Study; Lead; Leukocytes; Life; Link; Loneliness; Malignant Neoplasms; Measures; Medical; Morbidity - disease rate; Napping; Nature; Nuclear; Outcome; Pathway interactions; Patient Self-Report; Persons; Physiological; Polysomnography; Prevention; Production; Proteins; Questionnaires; REM Sleep; Recovery; Relative (related person); Research Design; Reverse Transcriptase Polymerase Chain Reaction; Risk; Sampling; Severities; Signal Pathway; Signal Transduction; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Social Environment; Social isolation; Social support; Survey Methodology; Surveys; System; Testing; actigraphy; cardiovascular risk factor; cytokine; depressive symptoms; diaries; disorder risk; experience; feeding; field study; genome-wide; inflammatory marker; middle age; mortality; neoplastic; physical conditioning; psychobiologic; public health relevance; research study; sleep regulation; social; stem; therapy development

DESCRIPTION (provided by applicant): Older adults who are socially isolated have increased risk of all-cause mortality, and several specific infectious, neoplastic, and cardiovascular diseases. However, the neurobiologic and genomic mechanisms of these effects remain largely unexplored. Our preliminary studies have found that subjective social isolation is associated with sleep disturbance as well as increases in markers of inflammation. The over-arching objective of this study is to evaluate subjective social isolation in older adults and the consequences of such social isolation for the homeostatic regulation of sleep and inflammatory biology dynamics. Given our findings that cellular and genomic activation of inflammatory markers occurs along with subjective social isolation as well as sleep disturbance, this study will test the consequences of naturalistic and experimental sleep loss on feelings of social connection and cellular and genomic markers of inflammation in socially isolated vs. socially integrated older adults. The study aims are: 1) to determine the nature and severity of disordered sleep in socially isolated older adults; 2) to evaluate cellular and genomic markers of inflammation in socially isolated older adults; and 3) to examine the contribution of sleep loss and recovery sleep to behavioral symptoms and cellular and genomic markers of inflammation in socially isolated older adults. Understanding the consequences of social isolation for the homeostatic regulation of sleep within the framework of an observational and experimental research design has implications for identifying the psychobiological pathways that might drive the link between social isolation and health. Given that sleep loss induces elevations in proinflammatory cytokine activity, dysregulation of the bi-directional relationship between sleep and cytokines may result in a feed-forward loop in which disrupted sleep and elevated proinflammatory cytokines create a vicious cycle exacerbating sleep and contributing to feelings of social disconnection. Results of this study have immediate clinical implications for the development of interventions that target disordered sleep with potential effects on morbidity and outcomes in subjectively socially isolated older adults. PUBLIC HEALTH RELEVANCE: Social isolation has significant health consequences in older adults, but it is not known how feelings of loneliness and loss of emotional connections lead to increases in disease risk. Given our evidence that social isolation is associated with sleep disturbance, and such sleep difficulties increase inflammation with consequences for a number of medical disorders including cardiovascular disorder, diabetes mellitus, and cancer, this study will examine the relationships between social isolation, sleep disturbance and inflammation in socially isolated older adults. This study will inform the development of potential treatments that target disordered sleep with possible prevention of disease outcomes in older adults who are socially isolated.

描述（由申请人提供）：社会孤立的老年人患有全因死亡率的风险增加，几种特定的感染性，肿瘤和心血管疾病。然而，这些作用的神经生物学和基因组机制在很大程度上尚未探索。我们的初步研究发现，主观的社会隔离与睡眠障碍以及炎症标记的增加有关。这项研究的整个目标是评估老年人的主观社会隔离，以及这种社会隔离对睡眠和炎症生物学动力学调节的后果。鉴于我们的发现，炎症标志物的细胞和基因组激活以及主观的社会隔离以及睡眠障碍，这项研究将测试自然主义和实验性睡眠丧失对社会隔离的社会隔离vs.社会隔离的社会联系以及炎症的感受的后果。该研究的目的是：1）确定社会孤立的老年人睡眠无序睡眠的性质和严重程度； 2）评估社会孤立的老年人的炎症的细胞和基因组标记； 3）检查社会孤立的老年人的睡眠丧失和恢复睡眠对行为症状以及炎症的细胞和基因组标记的贡献。了解社会隔离对观察和实验研究设计框架内睡眠调节的后果对识别可能推动社会隔离与健康之间联系的心理生物学途径的意义。鉴于睡眠损失会诱导促炎细胞因子活性的升高，因此睡眠与细胞因子之间双向关系的失调可能会导致馈送前循环，在该环路中，喂养前循环中断的睡眠和促进性细胞因子的升高会造成恶性循环加剧睡眠，并导致社会障碍的影响。这项研究的结果对靶向无序睡眠的干预措施的发展具有直接的临床意义，并潜在地影响了主观社会孤立的老年人的发病率和结果。 公共卫生相关性：社会隔离在老年人中具有重大的健康后果，但尚不知道孤独感和情绪联系的感觉如何导致疾病风险的增加。鉴于我们的证据表明社会隔离与睡眠障碍有关，而这种睡眠困难会增加炎症，并对多种医学疾病（包括心血管疾病，糖尿病和癌症）的影响，这项研究将研究社会隔离的老年人的社会隔离，睡眠障碍和炎症之间的关系。这项研究将为靶向无序睡眠的潜在治疗方法提供信息，并可能预防社会孤立的老年人的疾病结局。