Admin Core - Autophagy Modulators as Novel Broad-Spectrum Anti-Infective Agents

管理核心 - 自噬调节剂作为新型广谱抗感染剂

基本信息

批准号：
9893810
负责人：
HERBERT W VIRGIN
金额：
$ 30.91万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9893810
关键词：
Achievement Address Administrative Coordination Advisory Committees Animals Anti-Infective Agents Autophagocytosis Award Biology Cell Line Chemicals Collaborations Communication Communication Programs Complement Contracts Data Data Analyses Databases Ensure Evaluation Fostering Funding Generations Genes Goals Human Resources Individual Infrastructure Institution Laboratories Leadership Mediation Methodology National Institute of Allergy and Infectious Disease Participant Pathway interactions Preparation Process Progress Reports Quality Control Reagent Report (document)Reporting Research Research Activity Research Project Grants Resources Series Site Stream Teleconferences Therapeutic Time Travel United States National Institutes of Health base cohesion collaborative environment cost data exchange data sharing experimental study high throughput screening meetings member novel organizational structure priority pathogen programs therapeutic development therapeutic target

项目摘要

Project Summary – Administrative Core The Administrative Core will provide the requisite infrastructure to achieve the overall research objectives of the CETR. Effective scientific management and coordination by the Administrative Core will provide direction, oversight, and quality control for the research activities of each Project, and will maximize collaboration and exchange from all participating groups. Clear scientific leadership and direct communication by the Administrative Core will ensure optimal and transparent utilization of resources that promotes productive long- term relationships. The Administrative Core will promote data sharing, integration of projects, and communication, which will leverage the expertise of each member of the CETR to expedite discovery and achievement of the research goals. The Administrative Core will achieve several of these goals by providing a coherent stream of communication, which will begin by establishing monthly meetings between Program participants under the guidance of the Program Director. These meetings will be held through video teleconference and will promote data exchange, evaluation of progress and planning as it relates to the goals of the program and aims of individual projects. Each meeting will include discussion and analysis of results, goals and progress, as well as a forum for negotiation of key strategic decisions. The Administrative Core also will foster communication and organizational structure through preparation of financial reports and documents (e.g., progress reports) for the NIH. The Administrative Core will have specific financial responsibilities and obligations particularly as it relates to shared activities among CETR members. This will include costs associated with Scientific Advisory Committee travel and clerical/communication programs directly related to the CETR. Through these activities, the Administrative Core will ensure an interactive and collaborative environment, exchange of reagents and data, and foster a cohesive relationship among PIs of the CETR, which will enhance our direct goal of further developing novel autophagy-directed anti-infectives against NIAID priority pathogens.

项目摘要 – 行政核心行政核心将提供必要的基础设施，以实现该中心的总体研究目标 CETR。行政核心的有效科学管理和协调将提供方向，对每个项目的研究活动进行监督和质量控制，并将最大限度地合作和所有参与小组的交流。明确的科学领导和直接沟通。行政核心将确保资源的最佳和透明利用，促进生产性长期管理核心将促进数据共享、项目集成和沟通，这将利用 CETR 每个成员的专业知识来加快发现和行政核心将通过提供一个实现这些目标的几个目标。连贯的沟通流程，首先是在计划之间建立每月一次的会议与会者将在项目主任的指导下通过视频方式举行。电话会议，并将促进与目标相关的数据交换、进展评估和规划每次会议将包括对结果、目标的讨论和分析。和进展，以及关键战略决策谈判的论坛。通过准备财务报告和文件（例如， NIH 的行政核心将承担具体的财务责任和义务。特别是因为它涉及 CETR 成员之间的共同活动，这将包括与相关的成本。与 CETR 直接相关的科学咨询委员会旅行和文书/通讯计划。在这些活动中，行政核心将确保一个互动和协作的环境，交流试剂和数据，并在 CETR 的 PI 之间建立有凝聚力的关系，这将增强我们的直接进一步开发针对 NIAID 优先病原体的新型自噬导向抗感染药物的目标。