Evaluating New Nicotine Standards for Cigarettes - Core C

评估卷烟新尼古丁标准 - 核心 C

• 批准号: 9889095
• 负责人: Joseph S. Koopmeiners
• 金额: $ 22.96万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9889095
• 关键词: Biometry; Biostatistical Methods; Cigarette; Collaborations; Communities; Complex; Consultations; Data; Data Analyses; Data Analytics; Data Collection; Data Storage and Retrieval; Development; Ethics; Experimental Designs; Grant; Guidelines; Information Systems; Knowledge; Logistics; Methodology; Methods; Nicotine; Performance; Play; Procedures; Productivity; Protocols documentation; Public Health; Publications; Quality Control; Reporting; Research; Research Design; Research Methodology; Research Personnel; Resources; Sample Size; Science; Secure; Statistical Data Interpretation; Stratification; Techniques; Tobacco; United States National Institutes of Health; central database; cost effectiveness; data integrity; data management; data quality; data sharing; design; experience; interdisciplinary approach; member; novel; operation; programs; quality assurance; research and development; sound; statistical service; trial design

Core C – Biostatistics and Data Management The Biostatistics and Data Management Core provides a broad array of statistical services in support of the three Projects. The Core will provide advice on experimental design - such as selection of end points and possible stratification, consideration and calculation of sample size and statistical power. The Core is responsible for all aspects of data management in a secure central database with strong emphasis of data integrity and quality. The Core will form plans and perform expert statistical analyses in a format consistent between Projects using techniques that are state of the art in practice. The Core will also facilitate data sharing between projects in the Program as well as the general scientific community following NIH guidelines. The Core is staffed by one biostatistician serving as Protocol Manager (Data Manager) and three highly experienced biostatisticians who have daily working relationships with the Project investigators. The Core biostatisticians have been an integral part in the development of the proposed Program and have participated with this group of investigators the last 4-5 years of this current CENIC grant. The primary objective of the Biostatistics and Data Management Core is to contribute to the science and operation of the center by participating fully in its activities. Core Statisticians have broad long-standing expertise in experimental design, data collection, data storage, data analysis, and interpretation of results incorporating novel and complex statistical procedures as needed. By providing expertise research methodology and logistical support to data analytic activities with each Project, this Core will enhance data interpretation and scientific productivity.

核心 C – 生物统计学和数据管理 生物统计和数据管理核心提供广泛的统计服务以支持 三个项目将提供有关实验设计的建议——例如终点的选择和 可能的分层、样本量和统计功效的考虑和计算。 负责安全中央数据库中数据管理的各个方面，重点关注数据 核心将制定计划并以一致的格式进行专家统计分析。 项目之间使用最先进的实践技术也将促进数据共享。 该计划中的项目以及遵循 NIH 指南的一般科学界之间的合作。 核心人员由一名担任方案经理（数据经理）的生物统计学家和三名高级生物统计学家组成。 与项目研究人员有日常工作关系的经验丰富的生物统计学家。 生物统计学家是拟议计划制定过程中不可或缺的一部分，并参与了 在当前 CENIC 资助的最后 4-5 年里，我们与这组研究人员一起工作。 生物统计和数据管理核心的主要目标是为科学和数据做出贡献 核心统计员拥有广泛的长期经验，充分参与中心的运作。 实验设计、数据收集、数据存储、数据分析和结果解释方面的专业知识 根据需要纳入新颖且复杂的统计程序。 每个项目的数据分析活动的方法和后勤支持，该核心将增强数据 解释和科学生产力。