Molecular Analysis of Disease Pathways

疾病途径的分子分析

基本信息

批准号：
9528586
负责人：
Susan M Lunte
金额：
$ 224.52万
依托单位：
UNIVERSITY OF KANSAS LAWRENCE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-15 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9528586
关键词：
Basic Science Biochemical Biology Biomedical Engineering Biomedical Research Cardiovascular Diseases Centers of Research Excellence Chemicals Chemistry DNA Sequencing Facility Development Disease Disease Pathway Educational workshop Faculty Fostering Future Genetic Genomics Goals Health Individual Institutes Institution Investigation Kansas Laboratories Lung diseases Malignant Neoplasms Mentors Microfabrication Microfluidics Molecular Molecular Analysis Molecular Probes Phase Process Request for Proposals Research Research Infrastructure Research Personnel Research Project Grants Resources Science Scientist Structure Technology United States National Institutes of Health Universities Vision base design empowered genome sequencing implementation research improved interest meetings multidisciplinary nervous system disorder programs recruit symposium tool

项目摘要

SUMMARY/ABSTRACT This proposal requests support to continue the development of the Center for Biomedical Research Excellence for Molecular Analysis of Disease Pathways (CMADP), which was established in 2012. The scientific theme of the CMADP is the creation and implementation of enabling technologies for the investigation of the genetic, biochemical and physical origins of disease. The Center is organized and directed out of the Ralph N. Adams Institute for Bioanalytical Chemistry at the University of Kansas (KU). The Center capitalizes on the current strengths of KU in the fields of bioanalytical chemistry, molecular design, genomics and bioengineering. Three core labs were established during Phase I focused on providing tools for junior investigators working on the development or application of new enabling technologies to study disease pathways. These are the Genome Sequencing Core, the Synthetic Chemical Biology Core (formerly the Molecular Probes Core) and the Microfabrication and Microfluidics Core. The three cores have catalyzed biomedical research in the State of Kansas by enhancing the research of junior and senior investigators and attracting faculty involved in biomedical research to Kansas Board of Regents institutions. Our vision for Phase II is to continue to develop a center that encourages basic research scientists to develop enabling technologies that can be used to foster health related research. This will be accomplished by continuing to build a powerful research infrastructure that enhances the ability of faculty investigators to compete independently for individual NIH R01 and comparable research grants. Our long-term goal continues to be to attain a critical mass of successful, multidisciplinary, independent but collaborative investigators, and for our Core laboratories to become self-sustaining enterprises in the future.

摘要/摘要该提案请求支持继续发展生物医学卓越研究中心疾病途径分子分析（CMADP），成立于2012年。 CMADP 是创建和实施用于研究遗传、疾病的生化和物理起源。该中心由拉尔夫·亚当斯 (Ralph N. Adams) 组织和指导堪萨斯大学 (KU) 生物分析化学研究所。该中心充分利用当前 KU 在生物分析化学、分子设计、基因组学和生物工程领域的优势。三核心实验室是在第一阶段建立的，重点是为初级研究人员提供工具开发或应用新的使能技术来研究疾病途径。这些是基因组测序核心、合成化学生物学核心（以前的分子探针核心）和微加工和微流体核心。这三个核心通过加强以下方面的研究促进了堪萨斯州的生物医学研究初级和高级研究人员，并吸引参与生物医学研究的教师加入堪萨斯委员会摄政机构。我们第二阶段的愿景是继续发展一个鼓励基础研究的中心科学家开发可用于促进健康相关研究的支持技术。这将是通过继续建立强大的研究基础设施来提高教师的能力来实现研究人员独立竞争个人 NIH R01 和类似的研究资助。我们的长期目标仍然是获得足够数量的成功、多学科、独立但协作的研究人员，并让我们的核心实验室在未来成为自给自足的企业。