VENTILATION MODEL AND CNS INJURY IN BABOONS WITH BPD

BPD 狒狒的通气模型和中枢神经系统损伤

• 批准号: 7562442
• 负责人: TERRIE E INDER
• 金额: $ 6万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562442
• 关键词: Anti-Inflammatory Agents; Bronchopulmonary Dysplasia; Caring; Cerebrum; Child; Closure; Computer Retrieval of Information on Scientific Projects Database; Depth; Development; Ductal; Dysplasia; Environmental air flow; Face; Funding; Grant; Growth; Hemorrhage; Hippocampus (Brain); Histopathology; Human; Image; Impairment; Infant; Infarction; Injury; Institution; Magnetic Resonance Imaging; Modeling; Nature; Neonatal; Nitric Oxide; Papio; Pattern; Periventricular Leukomalacia; Primates; Research; Research Personnel; Resources; School-Age Population; Severities; Source; United States National Institutes of Health; antioxidant therapy; central nervous system injury; gray matter; improved; insight; neurobehavioral; prenatal; respiratory; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Advances in prenatal and neonatal care have significantly improved survival of the prematurely born infant, particularly the most immature. However, as these children approach school age, it is recognized that up to 50% face neurobehavioral challenges. The nature of the cerebral injury that underlies all of these neurobehavioral deficits is not yet fully understood, but common patterns of injury are found in the cerebral white matter including hemorrhage and cystic infarction known as periventricular leukomalacia (PVL). It is also increasingly recognized that there is primary or secondary injury in the cortical and deep gray matter and the hippocampus, which may relate to subsequent intellectual impairments. It is critical that we gain insight into how particular neonatal practices, such as respiratory support, may alter the nature and the severity of cerebral injury in these vulnerable infants. In this study we propose to investigate the nature of cerebral injury in a prematurely born primate model (Papio sp) developed as a model of bronchopulmonary dysplasia, utilizing both magnetic resonance imaging (MR) and histopathology. Our hypothesis is that the prematurely born baboon (Papio sp) will display a pattern of cerebral injury, evident on MR imaging and histopathology, similar to that found in the prematurely born human infant. Specific aim #1: Characterize the ontogeny of cerebral development in the prematurely born baboon Specific aim #2: Characterize the nature and severity of cerebral injury in the prematurely born baboon. Specific aim #3: Evaluate the Influence of three highly clinically relevent therapies aimed at reducing bronchopulomonary dysplasia (BPD) on the pattern of cerebral injury including nitric oxide, antioxidant therapies and anti-inflammatory agents aimed at ductal closure.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 产前和新生儿护理的进步显着提高了早产儿的存活率，尤其是最不成熟的婴儿。然而，随着这些儿童接近学龄，人们认识到高达 50% 的儿童面临神经行为挑战。所有这些神经行为缺陷背后的脑损伤的本质尚未完全清楚，但在脑白质中发现了常见的损伤模式，包括出血和囊性梗塞，称为脑室周围白质软化症 (PVL)。人们也越来越认识到，皮质、深层灰质和海马体存在原发性或继发性损伤，这可能与随后的智力障碍有关。至关重要的是，我们必须深入了解特定的新生儿实践（例如呼吸支持）如何改变这些脆弱婴儿脑损伤的性质和严重程度。在这项研究中，我们打算利用磁共振成像（MR）和组织病理学来研究早产灵长类动物模型（Papio sp）的脑损伤性质，该模型被开发为支气管肺发育不良模型。我们的假设是，早产狒狒（Papio sp）会表现出一种脑损伤模式，这在磁共振成像和组织病理学上很明显，与早产人类婴儿中发现的情况类似。 具体目标#1：描述早产狒狒大脑发育的个体发育特征 具体目标#2：描述早产狒狒脑损伤的性质和严重程度。 具体目标#3：评估旨在减少支气管肺发育不良（BPD）的三种临床高度相关疗法对脑损伤模式的影响，包括一氧化氮、抗氧化疗法和旨在闭合导管的抗炎药物。