STRUCTURAL BASIS OF AMBLYOPIA & STRABISMUS

弱视的结构基础

• 批准号: 7562142
• 负责人: JONATHON C HORTON
• 金额: $ 2.46万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562142
• 关键词: Action Potentials; Amblyopia; Behavior; Chromosome Pairing; Computer Retrieval of Information on Scientific Projects Database; Excitatory Postsynaptic Potentials; Fire - disasters; Funding; Grant; Institution; Lateral Geniculate Body; Neurons; Output; Probability; Research; Research Personnel; Resources; Retina; Retinal; Source; Strabismus; Synapses; Testing; Thalamic structure; United States National Institutes of Health; Visual system structure; base; retinogeniculate; transmission process; Action Potentials; Amblyopia; Behavior; Chromosome Pairing; Computer Retrieval of Information on Scientific Projects Database; Excitatory Postsynaptic Potentials; Fire - disasters; Funding; Grant; Institution; Lateral Geniculate Body; Neurons; Output; Probability; Research; Research Personnel; Resources; Retina; Retinal; Source; Strabismus; Synapses; Testing; Thalamic structure; United States National Institutes of Health; Visual system structure; base; retinogeniculate; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Transmission of Burst Firing at the Retinogeniculate Synapse: In the visual system, output from the retina is filtered through a thalamic relay station called the lateral geniculate nucleus (LGN) before transmission to the cortex. The probability that a given retinal action potential generates an action potential in a geniculate neuron is usually much less than 100%. It is possible, however, for a single retinal spike to generate more than one geniculate spike, because LGN firing behavior exists in two modes: tonic and burst. Burst spikes are defined as those occurring after a 100 ms pause, with an interspike interval of less than 4 ms. During the silent period, the low-threshold Ca2+ current (IT) becomes de-inactivated. Subsequently, a single retinal EPSP can cause a burst of geniculate action potentials riding on a large depolarizing Ca2+ current. We tested what happens to efficacy when an LGN neuron fires in burst mode, rather than tonic mode, during natural stimulation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：视网膜生成突触处的爆发发射的传播：在视觉系统中，视网膜的输出通过丘脑继电器站过滤，称为侧向基因核（LGN），然后再传输到皮层。给定的视网膜作用电位在统一神经元中产生动作电位的概率通常远小于100％。但是，单个视网膜尖峰可能会产生多个吉格峰，因为LGN发射行为以两种模式存在：滋补和爆发。爆发的尖峰定义为在暂停100 ms后发生的峰值，径流间隔小于4 ms。在静默期间，低阈值Ca2+电流（IT）被解散。随后，单个视网膜EPSP会导致在大型去极化Ca2+电流上骑行的一系列固定作用电位。我们测试了自然刺激期间LGN神经元以爆发模式而不是补品模式射击时的功效会发生什么。